TY  - JOUR
T1  - Klorzoksazonun antibakteriyel etkisinin belirlenmesi
TT  - Evaluation of antibacterial effects of chlorzoxazone
AU  - Norizadeh Tazehkand, Mostafa
AU  - Yılmaz, Mehmet Bertan
PY  - 2019
DA  - June
Y2  - 2019
DO  - 10.17826/cumj.459036
JF  - Cukurova Medical Journal
JO  - Cukurova Med J
PB  - Cukurova University
WT  - DergiPark
SN  - 2602-3032
SP  - 653
EP  - 658
VL  - 44
IS  - 2
LA  - tr
AB  - Amaç: Antibiyotik olmayan ilaçlarınbazıları, rutin kullanımlarında bakteri gelişimine karşı inhibisyon etkisağlayabilirler. Klorzoksazon, kas spazmı ve bununla birlikte ortaya çıkanağrıyı tedavi etmek için kullanılan kas gevşetici ilaçtır. Bu çalışmanın amacı Klorzoksazon‘un antibakteriyel etkilerinin MİK (minimum inhibitör konsantrasyon), MBK (minimumbakterisid konsantrasyon) ve disk difüzyon metodu ile incelenmesidir.Gereç ve Yöntem: Klorzoksazon’a karşı MİK ve MBKdeğerlerin belirlenmesi 2 farklı bakteri suşunda (gram negatif bakteri suşuolarak Pseudomonas aeruginosa ve gram pozitif bakteri suşu olarak Bacillussubtilis) seyreltmesi yöntemine göre belirlenmiştir. Disk difüzyon testiise üç farklı konsantrasyon (25, 50 ve 100 μg)’da yapılmıştır. Bulgular: Klorzoksazon’un Pseudomonasaeruginosa'ya karşı MİK değeri 800 mg mL-1, MBK değerleri ise2.56 mg mL-1 ve Klorzoksazon 'un Bacillus subtilis'e karşı MİKdeğerleri 0.400 mg mL-1, MBK değeri ise 1.92 mg mL-1 olarakbelirlenmiştir. Disk difüzyon deneyinden elde edilen sonuçlar Klorzoksazon’un Pseudomonasaeruginosa ve Bacillus subtilis üzerinde antibakteriyel etkisininolmadığı sonuçlanmıştır. Sonuç: Klorzoksazon’un antibakteriyelaktivitesinin olmamasına rağmen Klorzoksazon’un muhtemel riskini belirlemekiçin başka çalışmalara ihtiyaç vardır.
KW  - Antibakteriyel etki
KW  - Bacillus subtilis
KW  - Klorzoksazon
KW  - Pseudomonas aeruginosa
N2  - Purpose: Some of non-antibiotic drugs may provide inhibition against bacterial growth in their routine use. Chlorzoxazone is a muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. This study was aimed to the investigation of antibacterial effects of Chlorzoxazone using MIC (Minimum inhibitory concentration), MBC (minimum bactericidal concentration) and disk diffusion method.Materials and Methods: The MIC and MBC was determined by dilution assay using different concentrations of Chlorzoxazone against 2 bacterial strain (Pseudomonas aeruginosa as a gram negative bacterial strain and Bacillus subtilis as a gram positive bacterial strain). Disk diffusion assay were prepared at different doses (25, 50 and 100 µg).Results: MIC values of Chlorzoxazone against Pseudomonas aeruginosa was 0.800 mg ml-1, and MBC values was 2.56 mg ml-1 and MIC values of Chlorzoxazone against Bacillus subtilis was 0.400 mg ml-1, and MBC values was 1.92 mg ml-1. The results obtained from disk diffusion assay supported that the Chlorzoxazone has not antibacterial effect on Pseudomonas aeruginosa and Bacillus subtilis.Conclusion: Although antibacterial activity of Chlorzoxazone was not found but another studies are needed to determine the probable risk of Chlorzoxazone.
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UR  - https://doi.org/10.17826/cumj.459036
L1  - https://dergipark.org.tr/en/download/article-file/667572
ER  -