@article{article_460369, title={Assessment of tumor lysis syndrome cases}, journal={Cumhuriyet Medical Journal}, volume={41}, pages={28–33}, year={2019}, DOI={10.7197/223.vi.460369}, author={Hüzmeli, Can}, keywords={Tumor lysis syndrome,malignancy,hyperuricemia,acute renal damage}, abstract={<p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:normal;"> <b> <span lang="en-us" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-us">Objective: </span> </b> <span lang="en-gb" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-gb">Tumor lysis
syndrome (TLS) is a clinical picture that occurs with the rapid destruction of
tumor cells and with life-threatening metabolic disorders. The aim of our study
is to evaluate the etiologic causes, diagnosis and treatment of TLS cases. </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:normal;"> <b> <span lang="en-us" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-us">Method: </span> </b> <span lang="en-gb" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-gb">The study was
conducted between January 2015 and December 2017 in </span> <a> <span style="font-size:10pt;font-family:’Times New Roman’, serif;color:rgb(33,33,33);">Kahramanmaras
Necip Fazıl city Hospital </span> </a> <span lang="en-gb" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-gb">. </span> <span class="MsoCommentReference"> <span style="font-size:10pt;font-family:’Times New Roman’, serif;"> <a class="msocomanchor" href="#_msocom_1">[HT1] </a>  </span> </span> <span lang="en-gb" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-gb">A
total of 32 patients diagnosed with TLS were included in the study. Laboratory
values of patients were scanned (blood urea nitrogen, creatinine, potassium,
phosphorus, calcium, serum uric acid, lactate dehydrogenase) and diagnoses,
chemotherapy and treatments were noted. </span> <span lang="en-gb" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-gb"> </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:normal;"> <b> <span lang="en-us" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-us">Results: </span> </b> <span lang="en-gb" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-gb">Of the 32 patients
who were included in the study, 17 were male and 15 were female. The average
age of the patients was found as 62,06 ± 12,10 (35-86) years. Hematologic
malignancy was detected in the </span> <span lang="en-gb" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-gb"> etiology of
11 of the TLS cases and solid tumor was detected in 21 of the TLS cases. A
total of 12 (37.5%) patients had spontaneous TLS (5 in haematological
malignancy and 7 in solid tumor). Hyperpotassaemia 50%, hypocalcaemia 46.9%,
hyperphosphatemia, hyperuricemia and acute kidney damage was present in all
patients. Mortality rate was found as 40.6%. </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:normal;"> <b> <span style="font-size:10pt;font-family:’Times New Roman’, serif;">Conclusions: </span> </b> <span lang="en-gb" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-gb">In
our study, spontaneous TLS was detected at a high rate. In addition, the
mortality rate was also high. Early diagnosis and urgent treatment should be
planned to avoid mortalities. </span> <span lang="en-gb" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-gb"> </span> </p> <p> </p> <p class="MsoNormal"> </p> <p>  </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:normal;"> </p> <div> <hr class="msocomoff" align="left" size="1" width="33%" /> <div> <div class="msocomtxt"> <a> </a> <br /> </div> </div> </div> <div> <div> <div class="msocomtxt"> </div> </div> </div> <p> </p>}, number={1}, publisher={Sivas Cumhuriyet University}