@article{article_462067, title={Evaluation of dynamic thiol/disulfide homeostasis in patients with Familial Mediterranean Fever}, journal={Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi}, volume={9}, pages={21–25}, year={2018}, DOI={10.22312/sdusbed.462067}, author={Doğru, Atalay and Balkarlı, Ayşe and Yıldırım Çetin, Gözde and Neşelioğlu, Salim and Erel, Özcan and Şahin, Mehmet}, keywords={Ankylosing Spondylitis,Familial Mediterranean fever,Thiol/disulfide}, abstract={<p style="margin-top:0cm;margin-right:0cm;margin-bottom:10.05pt;margin-left:0cm;text-align:justify;line-height:200%;"> <b> <span lang="en-us" xml:lang="en-us">Introduction: </span> </b> <span lang="en-us" xml:lang="en-us"> Familial Mediterranean
fever (FMF) <span> is a hereditary autoinflammatory
disease </span>that <span>includes recurrent episodes
of serosal inflammation, with accompanying fever. </span> </span> <span lang="en-us" xml:lang="en-us">Thiol/disulfide
homeostasis, marker of oxidative stress, is associated with an increase in </span> <span lang="en-us" xml:lang="en-us">inflammatory cytokines in many inflammatory diseases. The aim was to
evaluate the </span> <span lang="en-us" xml:lang="en-us">dynamic
thiol/disulfide homeostasis </span> <span lang="en-us" xml:lang="en-us">in patients with FMF during
attack free period. </span> </p> <p style="margin-top:0cm;margin-right:0cm;margin-bottom:10.05pt;margin-left:0cm;text-align:justify;line-height:200%;"> <b> <span lang="en-us" xml:lang="en-us">Material and method: </span> </b> <span lang="en-us" xml:lang="en-us">In our study, <b> </b> </span> <span lang="en-us" xml:lang="en-us">60 patients with FMF during
attack free period, 60 patients with </span> <span lang="en-us" xml:lang="en-us">Ankylosing
Spondylitis ( </span> <span lang="en-us" xml:lang="en-us">AS)
during inactive period and 60 age-and sex matched controls were included. Native
thiol, total thiol and disulfide levels were measured by using the Erel and
Neselioglu method. </span> </p> <p> </p> <p style="margin-top:0cm;margin-right:0cm;margin-bottom:10.05pt;margin-left:0cm;text-align:justify;line-height:200%;"> <b> <span lang="en-us" xml:lang="en-us">Result: </span> </b> <span lang="en-us" xml:lang="en-us">Total thiol and disulfide levels were found to be significantly
lower in FMF group compared to healthy controls. Native thiol levels were
detected to be significantly higher in FMF group compared to AS group. However,
no significant difference was observed in total thiol levels between FMF and AS
group. Ratios obtained using plasma native thiol, total thiol, and disulfide
levels differed significantly between the FMF, AS and the control groups. </span> </p> <p> </p> <p style="margin-top:0cm;margin-right:0cm;margin-bottom:10.05pt;margin-left:0cm;text-align:justify;line-height:200%;"> <b> <span lang="en-us" xml:lang="en-us">Conclusion: </span> </b> <span lang="en-us" xml:lang="en-us">The lower thiol level of FMF
group compared to AS and controls suggests that the thiol / disulfide balance
is affected differently in diseases with different pathophysiology. Although
the disease is in clinically inactive period, inflammation may continue at
different levels in different rheumatic diseases. </span> </p>}, number={3}, publisher={Süleyman Demirel University}