TY  - JOUR
T1  - Sıçanlarda Akrilamid ile İndüklenen Oksidatif Strese Karşı Taurinin Koruyucu Etkisi
TT  - Protective Effect of Taurine Against Acrylamide-induced Oxidative Stress in Rats
AU  - İnce, Sinan
AU  - Acaröz, Ulaş
AU  - Arslan-acaröz, Damla
AU  - Varol, Nuray
AU  - Gürler, Zeki
AU  - Küçükkurt, İsmail
AU  - Demirel, Hasan Hüseyin
AU  - Eryavuz, Abdullah
PY  - 2018
DA  - December
Y2  - 2018
DO  - 10.30607/kvj.466888
JF  - Kocatepe Veterinary Journal
JO  - kvj
PB  - Afyon Kocatepe University
WT  - DergiPark
SN  - 2147-6853
SP  - 479
EP  - 490
VL  - 11
IS  - 4
LA  - tr
AB  - Bu çalışmada, sıçanlarda akrilamid ile oluşturulan oksidatif stresekarşı antioksidan ajan olan taurinin koruyucu etkisinin araştırılmasıamaçlandı. Toplam 35 Wistar erkek sıçan standart rodent yemiyle beslendi ve 5eşit gruba ayrıldı. I. Grup: kontrol grubu, II. Grup: sadece 15 mg/kgakrilamid 60 gün boyunca gastrik gavaj yolu ile verildi. III., IV. ve V.gruplara sırasıyla akrilamid (15 mg/kg) ve taurin 50, 100 ve 200 mg/kg/günolacak şekilde ağızdan gastrik gavaj ile verildi. Akrilamid uygulamasısıçanların kan ve dokularında malondialdehid seviyelerinde önemli bir artışa veglutatyon seviyelerinde azalmaya neden oldu. Buna ilave olarak, akrilamiduygulaması ile süperoksid dismutaz ve katalaz aktivitelerinin sıçan eritrositve dokularında azaldığı belirlendi. Taurin uygulamasının akrilamid ileindüklenen oksidatif stres ve lipid peroksidasyonu azaltarak vücudun antioksidan savunmasistemini iyileştirdiği belirlendi. Bunun yanı sıra, taurin uygulaması ile akrilamidverilen sıçanların karaciğer ve beyin dokularındaki IFN-γ, IL-1β, TNF-α ve NFĸBmRNA ekspresyon düzeylerinin azaldığı gözlendi. Ayrıca, taurindokularda akrilamid ile indüklenen oksidatif stres sonucu oluşan histopatolojikdeğişikliklere karşı koruyucu etki gösterdi. Sonuçta doza bağlı olarak taurininsıçanlarda antioksidan savunma mekanizmasını artırarak akrilamidle indüklenen oksidatif strese karşı koruyucu etkigösterdiği belirlendi.
KW  - Akrilamid
KW  - taurin
KW  - oksidatif stres
KW  - lipid peroksidasyon
KW  - sitokin
KW  - sıçan
N2  - The aim of thepresent study was to evaluate the protective effect of taurine on acrylamide-induced oxidative stress in rats.Totally, 35 Wistar albino male rats were fed standard rodent diet and dividedinto 5 equal groups. I. Group: control group, II. Group: only 15 mg/kg acrylamidetreated by gastric gavage for 60 days.III., IV., and V. group received 15 mg/kg acrylamide with taurine at dose of 50, 100 and 200 mg/kg/day by gastricgavage. Treatment with acrylamide significantly increased malondialdehydelevels and decreased glutathione levels in blood and tissues of rats.Additionally, acrylamide treatment decreased superoxide dismutase and catalaseactivities in erythrocyte and tissues of rats. However, treatment of taurineinhibited acrylamide-induced oxidative stress, lipid peroxidation, and enhancedthe antioxidant enzymes activities. Besides, mRNA expression levels of IFN-γ,IL-1β, TNF-α, and NFĸB in liver and brain of acrylamide exposed rats weredecreased with taurine treatment. Moreover, taurine exhibited protective actionagainst the acrylamide-induced histopathological changes in tissues. In conclusion, it wasdetermined that taurine in a dose-dependentmanner has a protective effect against acrylamide induced oxidative stress byincreasing antioxidant defense mechanism in rats.
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UR  - https://doi.org/10.30607/kvj.466888
L1  - https://dergipark.org.tr/en/download/article-file/556252
ER  -