@article{article_471617, title={RISK FACTORS ASSOCIATED WITH PERSISTENCE, RECURRENCE AND PROGRESSION OF CERVICAL INTRAEPITHELIAL NEOPLASIA (CIN) AFTER COLD KNIFE CONIZATION}, journal={Türk Jinekolojik Onkoloji Dergisi}, volume={16}, pages={44–48}, year={2013}, author={Go, Dimitrov and Gl, Dimitrov and E, Dzikova and S, Panov and M, Ceselkovska and Gj, Babusku}, keywords={Cold Knife Conization, CIN, HR- HPV Infection, Persistence, Recurrence.}, abstract={Objective: The aim of this study was to evaluate the significant risk factors that influence on persistence, recurrence and progression of CIN after cold-knife conization (CKC) Design: Prospective follow-up study. Methods: We retrospectively analyzed the likelihood of recurrent/residual disease in 143 pa-tients (mean age 39, 3 years, range 22 to 58 years) who underwent cold knife conization for CIN at the General Hospital Remedika, Department for Gynecology and Obstetrics, Skopje, Mace-donia in a period of 5 years. Results: Women with HR- HPV DNA after cold knife conization had a 17,5 % risk of reccur-ence, whereas 0,8% of women with absent HR – HPV DNA were with recurrent/persistent CIN. Conclusion: Persistence of HR-HPV DNA was only significant risk factor for recurrence and progression of cervical intraepithelial neoplasia (CIN) after Cold Knife Conization. Women with post-treatment HR-HPV types should be carefully followed-up every 4 months in a period of 2 years and all cytology abnormalities, followed by histological verification should be appropriately treated. Long-term follow-up strategy is obligatory because HR-HPV infection plays a predominant role in the pathogenesis of pre-invasive and invasive cervical cancer.}, number={2}, publisher={Türk Jinekolojik Onkoloji Derneği}