TY  - JOUR
TT  - RAT OVERİNDE OLUfiTURULAN ADNEKSİYAL TORSİYONMODELİNDE PERİOPERATİF SELENYUM VE C VİTAMİNİUYGULAMASININ OVARYAN NEKROZ ÜZERİNE ETKİNLİĞİNİNDEĞERLENDİRİLMESİ
AU  - Mesci Haftacı, Simender
AU  - Albayrak, Mustafa
AU  - Demir, Şerif
AU  - Yıldırım, Ümran
AU  - Ankaralı, Handan
AU  - Keskin, Fatih
PY  - 2013
DA  - October
JF  - Türk Jinekolojik Onkoloji Dergisi
JO  - TRSGO Dergisi
PB  - Türk Jinekolojik Onkoloji Derneği
WT  - DergiPark
SN  - 2148-5372
SP  - 0
EP  - 0
VL  - 16
IS  - 4
KW  - ‹skemi
KW  - Reperfüzyon
KW  - Over
KW  - Selenyum
KW  - C Vitamini
KW  - ‹skemi/reperfüzyon Hasar›.
N2  - Introduction: Ovarian torsion is a serious gynaecologic problem  in gynecologic oncology where conservative management includes  detorsion of the involved segments. Torsion has been implicated in  ovarian damage and loss of fertility, and detorsion in one of the most  important factors in further injury. Ovarian injury resulting from torsion/detorsion  resembles that caused by ischemia/reperfusion (I/R)  injury observed in other organs.  Aim: In this experimental study, the aim is to examine the effects  of Vitamin C and selenium on ischemia-reperfusion injury in the rat  ovary.  Materials and Methods: In this study 48 female Wistar rats were  used. In the Sham group(Group 1) only laparotomy was performed.  In group 2 (ischemia) ovarian ischemia was produced and the right  ovary was surgically removed 4 h later. In group 3(ischemia/reperfusion  ) an ischemic period of 4 h was followed by reperfusion for 1 h,  the right ovary was removed. In groups 4,5 and 6, after 4h of ischemia,  either vit C, selenium, selenium+vit C respectively were infused  before reperfusion; after 1 h of reperfusion the right ovary was  removed. The ovaries were examined by histopathologic evaluation.  Results: There was no cell injury in the Sham group but we determined  significant difference in the group of Vit C and selenium  infused together. In the ischemia group we determined cell injury was  less than ischemia/reperfusion group. The groups that have been  infused Vit C and selenium respectively, were similar with ischemia  group, but less than ischemia/reperfusion group.  Conclusion: We concluded that Vit C and selenium are effective  in decreasing ischemia/reperfusion injury
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UR  - https://dergipark.org.tr/en/pub/trsgo/article/471685
L1  - https://dergipark.org.tr/en/download/article-file/555855
ER  -