@article{article_476438, title={Evaluation of serum vitamin D levels in premenopausal women with iron deficiency anemia}, journal={The European Research Journal}, volume={6}, pages={232–237}, year={2020}, DOI={10.18621/eurj.476438}, author={Atalay, Eray and Bilgehan, Gökhan and Şişman, Pınar and Erdoğdu, Halil İbrahim}, keywords={Vitamin D,iron deficiency anemia,anemia}, abstract={<p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span lang="en-us" style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Objectives: </span> </b> <b> <span lang="en-us" style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> </span> </b> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;"> <span style="font-size:18px;">In recent years, many effects of
vitamin D except on bone metabolism have been discovered. Vitamin D contributes
to the correction of the anemia by acting on the erythroid precursors in the
bone marrow via Vitamin D Receptor and provides the elimination of free
radicals and prooxidant substances secondary to iron deficiency due to its
antioxidant effect in iron deficiency anemia (IDA). </span> </span> </p> <p> </p> <span style="font-size:18px;"> </span> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span lang="en-us" style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Methods: </span> </b> <span lang="en-us" style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;"> <span style="font-size:18px;">A total of 97 female premenopausal
women aged 18-44 were included in the study. Fifty patients with hemoglobin
levels below 12 mg/dl and iron deficiency were classified as IDA group, and 47
subjects with hemoglobin levels of 12 mg/dl and above were classified as
control group. The demographic data and biochemical parameters of all patients
included in the study were analyzed. </span> </span> </p> <p> </p> <span style="font-size:18px;"> </span> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span lang="en-us" style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Results: </span> </b> <span lang="en-us" style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;"> <span style="font-size:18px;">The vitamin D of the patient group
was found to be 7.87 ± 3.63 ng/ml and the vitamin D of the control group was
11.84 ± 6.72 ng/ml. The difference between the groups was statistically
significant. There was a positive correlation between serum vitamin D and serum
hemoglobin, hematocrit, serum MCH, serum iron level, transferrin saturation
index, ferritin. </span> </span> </p> <p> </p> <span style="font-size:18px;"> </span> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span lang="en-us" style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Conclusions: </span> </b> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;">In the light of the results of our study and other studies in the
literature, we think that vitamin D deficiency may be important in patients
with IDA and that vitamin D deficiency in these individuals will contribute to
the regulation of anemia due to positive effects of vitamin D on both
erythropoiesis and hepcidin in IDA are considered. However, larger studies are
needed to clarify this issue.  </span> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> </span> </p> <p> </p>}, number={3}, publisher={Prusa Medical Publishing}