TY  - JOUR
T1  - International Standards of Microbiological Quality in Cosmetic Products
AU  - Algın Yapar, Evren
AU  - Cengiz, Gökhan
PY  - 2018
DA  - December
DO  - 10.38093/cupmap.480119
JF  - Current Perspectives on Medicinal and Aromatic Plants
JO  - CUPMAP
PB  - Nazım ŞEKEROĞLU
WT  - DergiPark
SN  - 2619-9645
SP  - 120
EP  - 122
VL  - 1
IS  - 2
LA  - en
AB  - Blue and greencosmetics are sensitive products for microbial contamination and reducing thecontamination producing according to Cosmetic Good Manufacturing Practice (ISO22716), providing proper storage condition and packaging are effective factors. In additionantimicrobial effective preservatives can be added to protect the cosmeticproducts.1,2 Generally, preservatives are chemical substrates thatare effective on cytoplasm (conjugation mechanism, ribosomes, nucleic acids,thiol groups, amino groups), cell wall and cytoplasm membrane (membranepotential, enzymes, membrane penetration).3 The neutralization ofthe antimicrobial effect of the preservatives in microbiological qualitycontrol of cosmetics is essential for the safety of the tests. Theantimicrobial preservative in the cosmetic which is transferred to the mediumaffects the test negatively. The neutralization process can be carried outaccording to international standards used in microbiological analysis ofcosmetic products. The neutralization of preservatives in cosmetics can beperformed by adding of neutralizing agents in solvent, medium and/or washingsolution. The agents which are reacted with the preservative groups for theremoval of antimicrobial affect are used for this neutralization process whichis necessary for the removal of antimicrobial effect. According to EuropeanPharmacopeia 2.6.12. sodium bisulfite for glutaraldehyde and mercury compounds;dilution for sorbates and aldehydes; lecithin, polysorbate 80, saponin forquaternary ammonium compounds, parabens and iodines; thioglycollate formercurial; thiosulfate for halogens can be used as neutralizing agents.4Lecithin, polysorbate 80 for parabens, phenoxyethanol, phenylethanol; Lecithin,saponin, polysorbate 80, sodium dodecyl sulphate for quaternary ammoniumcompounds and cationic surfactants; glycine, histidine for aldehydesformaldehyde-release agents; sodium thiosulphate for oxidizing agents; sodiumbisulphate, L-cysteine and thioglycollic acid for metallic salts can be addedto the medium, solvent and/or washing solutions according to ISO 21149.5For the removal of antimicrobial effect, neutralizing agents in properconcentrations should be added to medium, solvents and washing solutions. Theaddition of these agents with antimicrobial effect should be proved by thestudies of conformity. Neutralizing agents react with antimicrobial agents toeliminate the antimicrobial effect.
KW  - Cosmetic product
KW  - Antimicrobial preservative
KW  - Standards
KW  - Quality control
CR  - 1.	Republic Turkey Ministry of Health. Turkish Medicines And Medical Devices Agency Cosmetic Law, 2005, No, 25823.
CR  - 2.	Republic Turkey Ministry of Health. Turkish Medicines And Medical Devices Agency, Guidance on Microbiological Control of Cosmetic Products Version 1.0.
CR  - 3.	ISO 17516, Cosmetic microbiology microbiological limits, 2014.
CR  - 4.	ISO 21149, Cosmetic microbiology enumeration and detection of aerobic mesophilic bacteria, 2006.
CR  - 5.	ISO 16212, Cosmetic microbiology enumeration of yeast and mould, 2008.
CR  - 6.	ISO 21150, Cosmetic microbiology detection of Escherichia coli, 2006.
CR  - 7.	ISO 22717, Cosmetic microbiology detection of Pseudomonas aeruginosa, 2006.
CR  - 8.	ISO 22718, Cosmetic microbiology detection of Staphylococcus aureus, 2006.
CR  - 9.	ISO 18416, Cosmetic microbiology detection of Candida albicans, 2007.
CR  - 10.	European Pharmacopoeia 9.0, 2.6.12. Microbiological exaimination of non-sterile products: microbial enumeration tests, 2017.
CR  - 11.	European Pharmacopoeia 9.0, 2.6.13. Microbiological exaimination of non-sterile products: Test for specified micro-organisms, 2017.
UR  - https://doi.org/10.38093/cupmap.480119
L1  - https://dergipark.org.tr/en/download/article-file/613543
ER  -