TY - JOUR T1 - İntranazal Salbutamolün Allerjik Rinitli Çocuk Hastalarda Görülen Burun Tıkanıklığı Üzerine Etkisi TT - Effect of Intranasal Salbutamol on the Nose Obstruction Seen in Pediatric Patients with Allergic Rhinitis AU - Yalım, Sıdıka Deniz AU - Asilsoy, Suna AU - Yılmaz, İsmail AU - Durmaz, Cemile AU - Usta Güç, Belgin PY - 2019 DA - July Y2 - 2019 DO - 10.17517/ksutfd.480722 JF - Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi JO - KSU Medical Journal PB - Kahramanmaras Sutcu Imam University WT - DergiPark SN - 1303-6610 SP - 66 EP - 68 VL - 14 IS - 2 LA - tr AB - Amaç: Atopik alerjik rinitliçocuk hastalarda intranazal salbutamol uygulanmasının etkisi olup olmadığınıaraştırmak.Gereç ve Yöntemler:Yaşları 6 ile 17 arasında atopik alerjik rinitli on altı çocuk hastaya (9erkek, 7 kız) intranazal salbutamol uygulandıve ilaç uygulamasından önce ve hemen sonra akustik rinometri iledeğerlendirildi.Bulgular: İntranazal salbutamoluygulamasından önce ve sonra sol ve sağ nazal kaviteler arasında CSA(Çaprazkesit alanı)1 SD(standart deviasyon) ve ayrıca sağ nazal kavitede CSA1 alanı veCSA3 mesafesi arasında istatistiksel olarak anlamlı fark vardı.Sonuç: İntranazal salbutamoluygulaması atopik alerjik rinitli çocuk hastalarda hiçbir yan etkisi olmaksızınfaydalıdır. Ayrıca intranazal salbutamol akut burun tıkanıklıklarında kurtarıcıilaç olarak kullanılabilir. KW - intranazal KW - salbutamol KW - allerjik rinit N2 - Objective: To investigate whetherintranasal salbutamol has efficacy in pediatric patients with allergic rhinitiswith atopy.Material and Methods: Sixteen pediatricpatients (9 boy, 6 girl) with allergic rhinitis with atopy within age between 6and 17 years were administered intranasal salbutamol and evaluated withacoustic rhinometry before and just after theadministration of the drug. Results: There was astatistically significant difference between CSA1 SD in both left and rightnasal cavities, and also in CSA1 area, CSA3 distance in right nasal cavitybefore and after salbutamol administration.Conclusion: Intranasal salbutamoladministration is effective in pediatric patients with allergic rhinitis withatopy without side effect. Also intranasal salbutamol may be used as a rescuemedicine in acute nasal obstructions. CR - Blaiss MS. Pediatric allergic rhinitis: Physical and mental complications. Allergy Asthma Proc 2008: 29(1): 1-6. CR - Corey JP. Acoustic Rhinometry: Should we be using it? Curr Opin Otolaryngol Head Neck Surg 2006: 14: 29-34. CR - Slavin RG. The upper and lower airways: The epidemiological and pathophysiological connection. Allergy Asthma Proc 2008: 29: 553-556. CR - Aas K. Some variables in skin prick testing. Allergy 1980: 35: 250-2. CR - Proud D, Reynolds CJ, Lichtenstein LM, Kagey-Sobotka A, Togias A. Intranasal salmeterol inhibits allergen-induced vascular permeability but not mast cell activation or cellular infiltration. Clin Exp Allergy 1998: 28(7): 868-75. CR - Schmidt WF, Waters RM, Mitchell AD, Warthen JD, Honigberg Jr IL, Van Halbeek H. Int J Pept Protein Res 1993: 41(5): 467-75. CR - Wecksler N, Brill S, Tarnapolski A, Gurman GM. Intranasal salbutamol instillation in asthma attack. Am J Emerg Med 1999: 17(7): 686-8. CR - Hussain AA, Dakkuri A, Lai YL, Traboulsi A, Hussain MA. Nasal administration of albuterol: an alternative route of delivery. J Pharm Pharmacol 2004: 56(10): 1211-5. CR - Hussain AA, Diamond L, Thompson D, Latta J, Dittert LW. Intranasal administration of a beta adrenergic amine: an alternative to metered dose inhalers. Ann Allergy 1992: 69(1): 26-9. CR - Tay HL, Armoogum N, Tan LK. Nasal mucociliary clearance and salmeterol. Clin Otolaryngol Allied Sci 1997: 22(1): 68-70. CR - Roberts DN, Birchall MA, East CA, Scadding G. Inranasal salbutamol has no effect on mucociliary clearance in normal subjects. Clin Otolaryngol Allied Sci 1995: 20(3): 246-8. CR - Stewart EJ, Cinnamond MJ, Nicholls P, Stanford CF. The influence of beta-adrenoceptors on nasal mucosal function. Rhinology 1993: 31(3): 121-4. CR - Russo C, Zeng D, Prosperini G, Spicuzza L, Guarino F, Polosa R. Effect of salbutamol on nasal symptoms and mast cell degranulation induced by adenosine 5’ monophosphate nasal challenge. Clin Exp Allergy 2005: 35(9): 1192-6. CR - Di Lorenzo G, Morici G, Norrito F, Mansueto P, Melluso M, Purello D’Ambrosio et al. Comparison of the effects of salmeterol and salbutamol on clinical activity and eosinophil cationic protein serum levels during the polen season in atopic asthmatics. Clin Exp Allergy 1995: 25(10): 951-6. CR - Piatti G, Ambrosetti U, Santus P, Allegra L. Effects of salmeterol on cilia and mucus in COPD and pneumonia patients. Pharmacol Res 2005: 51(2): 165-8. UR - https://doi.org/10.17517/ksutfd.480722 L1 - https://dergipark.org.tr/en/download/article-file/710013 ER -