@article{article_482403, title={Tea Tree Oil and Its Use in Aromatherapy}, journal={Current Perspectives on Medicinal and Aromatic Plants}, volume={1}, pages={90–102}, year={2018}, author={Çalışkan, Ufuk and Özfenerci, Müjgan}, keywords={Aromatherapy,Melaleuca alternifolia,TTO,Tea tree,phytotherapy}, abstract={<p class="Standarduser" style="text-align:justify;line-height:115%;"> <span style="font-size:10pt;line-height:115%;font-family:Cambria, serif;color:#222222;">Tea tree oil or TTO as it is widely known, is an essential oil with a pale yellow color and distinctive odor, obtained by steam distillation from the leaves of <i>Melaleuca alternifolia </i>, which is a native Australian plant. <i> In vitro </i> and <i> in vivo </i> research have shown that it has mainly, antibacterial, antiviral, antifungal as well as anti-inflammatory properties. </span> <span style="font-size:10pt;line-height:115%;font-family:Cambria, serif;"> <span style="color:#222222;">TTO is composed of terpene hydrocarbons, namely the main monoterpenes, sesquiterpenes and their associated alcohols. Three of its well-known compounds are 1.8-cineol, α-terpineol and terpinen-4-ol, the latter being the most active one. The ability of these components to disrupt the permeability of cytoplasmic membrane structures of bacteria makes TTO effective on methicillin-resistant bacteria and predominant especially in hospital-acquired <i>Staphylococcus aureus </i> infections. In this review historical, and morphological information about <i>M. alternifolia </i> plant, chemical properties related to TTO and the mechanism of antimicrobial, antiviral and antifungal actions will be explained, relying extensively on existing literature. </span> Diverse mixtures made of fixed and <span style="color:#222222;">essential </span> oils relating to TTO that are used as a broad-spectrum antibacterial for some skin infections and acne; for some vaginal fungus infections; for throat infections; for aphthae and cold sore on the basis of the oil’s antiviral effect; for skin and nail fungus on the basis of its antifungal property as well as TTO’s use in aromatherapy and phytocosmetics will also be illustrated. </span> <span lang="tr" xml:lang="tr"> </span> </p> <p> </p>}, number={2}, publisher={Nazım ŞEKEROĞLU}