TY  - JOUR
T1  - New Antiproliferative Acyl Glycerols from New Zealand Propolis and Source Poplar Resin
AU  - Bloor, Stephen
AU  - Catchpole, Owen
AU  - Mıtchell, Kevin
AU  - Webby, Rosemary
PY  - 2018
DA  - December
JF  - Journal of Apitherapy and Nature
JO  - J.Apit.Nat.
PB  - Oktay YILDIZ
WT  - DergiPark
SN  - 2667-4734
SP  - 18
EP  - 18
VL  - 1
IS  - 3
LA  - en
AB  - Previous work has shown a number ofphenolic components of NZ propolis demonstrate antiproliferative activityagainst certain human gastrointestinal cancer cell lines1.  Here we report on a series of acyl glycerolsisolated from the non-polar fraction of propolis resin, which represent furtherbioactive constituents unrelated to the more usual phenolic compounds generallyfound in propolis. NZ propolis is sourced from poplar trees and the acylglycerols have been shown to be present in the leaves and buds of some commonpoplars.  The compounds are a series ofmonoglycerides containing 3,8-dihydroxy fatty acids, many of which are furtheracylated with acetic acid residues. The dihydroxy fatty acids are C18 to C24,with the most abundant being C20 and C22. These acyl glycerols were found tohave strong antiproliferative activity against three human gastro-intestinalcell lines, particularly gastric cancer cell line NCI-N87.                                
KW  - New Zealand Propolis
KW  - Acyl Glycerols
KW  - Antiproliferative
CR  - 1. Catchpole, O., Mitchell, K., Bloor, S., Davis, P., Suddes, A. (2015). Antiproliferative activity of New Zealand propolis and phenolic compounds vs human colorectal adenocarcinoma cells. Fitoterapia. 106, 3257: 167-174
UR  - https://dergipark.org.tr/en/pub/jan/issue//488626
L1  - https://dergipark.org.tr/en/download/article-file/582790
ER  -