@article{article_493785, title={The Effect of N-Acetylcysteine on Fibrosis in Experimental Rat Chronic Pancreatitis}, journal={Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi}, volume={6}, pages={26–32}, year={2019}, author={Ocal, Ramazan and Tascı, İlker and Devecı, Mehmet Salih and Comert, Bilgin and Isık, Ahmet Turan and Mas, Mehmet Refik}, keywords={Animal Model,Experimental Chronic Pancreatitis,Fibrosis,N-Acetylcysteine}, abstract={<p> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <span lang="en-us" style="font-size:8pt;line-height:115%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> <span style="font-size:18px;">In this study, we
aimed to assess the effect of N-acetylcysteine on fibrosis, atrophy and
oxidative stress with chronic pancreatitis in an animal model. Chronic
pancreatitis is stimulated by injection of 0.4 ml, 2% trinitrobenzene sulfanic
acid (TNBS) into major pancreatic ducts of the rats. 60 Sprague-Dawley rats
were randomized into four group; Group I (n=15): saline (control), Grup II
(n=15): fibrosis + N-acetylcysteine (NAC), Grup III (n=15): fibrosis (TNBS),
Grup IV: ethanol. At the end of the 8th week, all rats were sacrificed, and rat
pancreatic tissues, oxidative stress markers and progression of fibrosis and
atrophy were examined. superoxide dismutase (SOD) and glutation peroxidase
(GSH-Px) activities were significantly higher with respect to TNBS group
(respectively p<0.001 and p<0.001); whereas tissue malondialdehyde (MDA)
levels were found significantly lower in NAC group (p<0.001).  </span> <span style="font-size:18px;">Histopathological analysis of the tissues
revealed that histopathological score of NAC group was significantly lower than
TNBS group (p<0.003), and was found a significant relation between increase
in oxidative stress and histopathological score (histopathological score/MDA:
p<0.03, SOD: p<0.04, GSH-Px: p<0,02). In conclusion, administration of
NAC decreases oxidative stress in chronic pancreatitis and has beneficial
effects on fibrosis and atrophy. </span> </span> <br /> </p> <p> <b> </b> </p> <b> </b>}, number={1}, publisher={Mugla Sitki Kocman University}