TY  - JOUR
T1  - Epidemiology of Candida colonization in medical surgical intensive care unit of a tertiary care teaching hospital of North India
AU  - Ahmed, Armin
AU  - Azim, Afzal
AU  - Baronia, Arvind Kumar
AU  - Yadav, Reema
AU  - Sharma, Preeti
AU  - Marak, Rungmei S. K.
PY  - 2018
DA  - December
DO  - 10.5799/jmid.493851
JF  - Journal of Microbiology and Infectious Diseases
JO  - J Microbil Infect Dis
PB  - Aydın ECE
WT  - DergiPark
SN  - 2146-3158
SP  - 147
EP  - 152
VL  - 08
IS  - 04
LA  - en
AB  - Objective: Invasive candidiasis is associated with increasedmorbidity and mortality in critically ill patients. Current study was undertakento study the colonization trend in critically ill patients admitted to amedical /surgical ICU of a tertiary care teaching hospital.Methodology: Data for the current study has been derived from alarger database generated for external validation of risk prediction scores forinvasive candidiasis conducted in a 12 bedded medical/surgical ICU of atertiary care hospital of North India. Non neutropenic adult patients with>48 hours of ICU stay were included in the study. Colonization surveillancesamples were collected from oral cavity, endotracheal aspirates, axilla,perineum and urine at the time of admission and then on 3rd, 7th,14th and 21st day of ICU stay. Blood culture samples weretaken at admission and then as per physician’s discretion.Results:Total 200 patients were enrolled from July 2013 to November 2014. Ninety fivepercent patients were colonized with Candidaeither at admission or during their stay in ICU. The most common speciesresponsible for colonization was Candidaglabrata (27%) followed by C.tropicalis (20.5%) and C. auris(18%). Seventeen patients developed Candidablood stream infection. C. tropicaliswas the most common species causing candidemia. C.auris was most frequentcolonizer of axilla (54.2%), while rectal swabs had high growth of C. glabrata (44.9%). Conclusion: Our study population had high rate of Candida colonization. C. glabrata was the most commoncolonizer followed by C. tropicalis.  JMicrobiol Infect Dis 2018; 8(4):147-152.
KW  - Candida auri
KW  - Candida colonization
KW  - Candida glabrata
KW  - Candida tropicalis; critically ill
CR  - 1.	Umscheid CA, Mitchell MD, Doshi JA, Agarwal R, Williams K, Brennan PJ. Estimating the proportion of healthcare-associated infections that are reasonably preventable and the related mortality and costs.Infect Control HospEpidemiol 2011; 32(2):101-14.
2.	De Rosa FG, Corcione S, Pagani N, Di PerriG. From ESKAPE to ESCAPE, from KPC to CCC.Clin Infect Dis 2015; 60 (8):1289-1290. 
3.	De Rosa FG, Corcione S, Raviolo S, et al. Candidemia, and infections by Clostridium difficile and carbapenemase-producing Enterobacteriaceae: new enteropathogenetic opportunistic syndromes? Infez Med 2015; 23(2):105-116.
4.	Kullberg BJ, Arendrup MC. Invasive Candidiasis. N Engl J Med 2015; 373(15):1445-1456. 
5.	Pittet D, Monod M, Suter PM, Frenk E, Auckenthaler R. Candida colonization and subsequent infections in critically ill surgical patients.Ann Surg 1994; 220(6):751-758.
6.	Eggimann P, Pittet D. Candida colonization index and subsequent infection in critically ill surgical patients: 20 years later. Intensive Care Med 2014; 40(10):1429-1448. 
7.	León C, Ruiz-Santana S, Saavedra P, et al. Study Group. A bedside scoring system ("Candidascore") for early antifungal treatment in nonneutropenic critically ill patients withCandida colonization.Crit Care Med 2006; 34(3):730-737.
8.	León C, Ruiz-Santana S, Saavedra P, et al. Cava Study Group. Usefulness of the "Candidascore" for discriminating between Candida colonization and invasive candidiasis in non-neutropenic critically ill patients: a prospective multicenter study.Crit Care Med 2009; 37 (5):1624-1633.
9.	Schulte DM, Sethi A, Gangnon R, Duster M, Maki DG, Safdar N. Risk factors for Candida colonization and Co-colonization with multi-drug resistant organisms at admission. Antimicrob Resist Infect Control 2015; 4:46. 
10.	Hamet M, Pavon A, Dalle F, et al. Candida spp. airway colonization could promote antibiotic-resistant bacteria selection in patients with suspected ventilator-associated pneumonia. Intensive Care Med 2012; 38 (8):1272-1279. 
11.	Ricard JD, Roux D. Candida colonization in ventilated ICU patients: no longer a bystander! Intensive Care Med 2012; 38(8):1243-1245. 
12.	Lau AF, Kabir M, Chen SC, et al.Candida colonization as a risk marker for invasive candidiasis in mixed medical-surgical intensive care units: development and evaluation of a simple, standard protocol. J Clin Microbiol 2015; 53 (4):1324-1330. 
13.	Ahmed A, Baronia AK, Azim A, et al. External Validation of Risk Prediction Scores for Invasive Candidiasis in a Medical/Surgical Intensive Care Unit: An Observational Study. Indian J Crit Care Med 2017; 21(8):514-520. 
14.	Nace HL, Horn D, Neofytos D. Epidemiology and outcome of multiple-species candidemia at a tertiary care center between 2004 and 2007. Diagn Microbiol Infect Dis 2009;64:289-294.
15.	Chakrabarti A, Sood P, Rudramurthy SM, et al. Incidence, characteristics and outcome of ICU-acquired candidemia in India.Intensive Care Med 2015; 41 (2):285-295.
UR  - https://doi.org/10.5799/jmid.493851
L1  - https://dergipark.org.tr/en/download/article-file/591181
ER  -