TY  - JOUR
T1  - Antalya Eğitim ve Araştırma Hastanesi multipl skleroz polikliniğinin oral tedavi deneyimi
TT  - Oral treatment experience in multiple sclerosis at Antalya Training and Research Hospital
AU  - Yüksel, Burcu
AU  - Kurtuluş, Fatma
AU  - Erdal, Abidin
PY  - 2019
DA  - May
Y2  - 2019
DO  - 10.31362/patd.500441
JF  - Pamukkale Medical Journal
JO  - Pam Med J
PB  - Pamukkale University
WT  - DergiPark
SN  - 1308-0865
SP  - 281
EP  - 287
VL  - 12
IS  - 2
LA  - tr
AB  - Amaç: Bu çalışmanın amacı Sağlık BilimleriÜniversitesi Antalya Eğitim ve Araştırma Hastanesi multipl skleroz (MS)polikliniğinin oral tedavi deneyimini paylaşmak, hastalar için uygun tedaviyiseçmenin önemini vurgulamaktır.Gereç ve yöntem: 2012-2018 yılları arasında MSpolikliniğinde en az 6 aydır düzenli takip edilen 550 hastanın dosyasıretrospektif olarak incelendi. Demografik veriler, daha öncesinde kullanmaktaolduğu tedaviler ve hangi sebeple (relaps sıklığında artış, progresyon, MR aktivasyonu,hasta isteği, önceki ilaca bağlı yan etki) oral tedavi tercih edildiği,hastalık süreleri ve ne kadar süredir oral tedavi kullanmakta oldukları,hastalık dizabilitesini ölçen Expanded Disability Status Scale (EDSS) skorları kaydedildi. Bulgular: 2010 McDonald kriterlerine göre kesin MStanısı alan 550 hasta çalışmaya dahil edildi. 108 (%19,6) hasta oraltedavilerden (fingolimod, dimetilfumarat ya da teriflunomid) birinikullanmaktaydı. 53 hasta (%49,1) fingolimod, 34 hasta (%31,5) dimetilfumarat,21 hasta (%19,4) teriflunomid kullanmaktaydı. En fazla atak sıklığında artışnedeniyle oral tedavi tercih edildiği saptandı.Sonuç: Oral tedavi kulanım oranımız Türkiyeortalamasının altında olsa da bulgularımız, tedavi değişimi yaptığımızda tedavipenceresi içinde kaldığımızı göstermektedir.
KW  - multipl skleroz
KW  - fingolimod
KW  - dimetilfumarat
KW  - oral tedavi
KW  - teriflunomid
N2  - Purpose: Our aim was to share our oral treatment experience in multiple sclerosis and howwe decided to choose the right treatment for our patients.Materials and methods: We analyzed multiple sclerosis patientswho were admitted to neurology clinic between 2012-2018. Demographic features,treatments that were used before initiating oral therapies, in which conditionsthe treatments were changed to oral therapies (increased relaps rate,progression, activation on magnetic resonance imaging, patient’s choice,adverse events with the previous treatment), the duration of the disease andthe oral treatment, Expanded Disability Status Scale (EDSS) scores were all recorded.Results: 550 patients with a definite clinicaldiagnosis of MS according to the 2010 McDonaldcriteria wereenrolled. 108 (19.6%) patients were receiving oral treatment for multiplesclerosis. 53 patients (49.1%) were receiving fingolimod, 34 patients (31.5%)were receiving dimethylfumarate, 21 patients (19.4%), were receivingteriflunomide. The most evident cause for changing the treatment was theincreased relaps rate.Conclusion: Although the ratio (19.6%) seemed to belower than the ratio from whole Turkey (41%), the timing of the treatmentchange have been shown to be in therapeutic window.
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UR  - https://doi.org/10.31362/patd.500441
L1  - https://dergipark.org.tr/en/download/article-file/725417
ER  -