TY  - JOUR
TT  - The Relationship between Proliferative Scars and Endothelial Function in Surgically Revascularized Patients
AU  - Ziyrek, Murat
AU  - Şahin, Sinan
AU  - Acar, Zeydin
AU  - Şen, Onur
PY  - 2015
DA  - October
JF  - Balkan Medical Journal
PB  - Trakya University
WT  - DergiPark
SN  - 2146-3123
SP  - 377
EP  - 381
VL  - 32
IS  - 4
KW  - Endothelium
KW  - keloid
KW  - cicatrix
KW  - wound healing
N2  - Background: Proliferative scars are benign fibrotic proliferations which demonstrate abnormal wound healing in response to skin injuries. As postulated in the “response to injury hypothesis”, atherosclerosis is also triggered by an endothelial injury. Keloid and atherosclerotic processes have many pathophysiological and cytological features in common.     Aims: In this study, we investigated the relationship between proliferative scars and endothelial function in surgically revascularized patients. We aimed to test the hypothesis that atherosclerosis is a wound healing abnormality.     Study Design: Cross-sectional study.     Methods: Consecutive patients who were admitted to the cardiology outpatient clinic with a history of coronary artery bypass grafting operation were evaluated. Thirty-three patients with proliferative scars at the median sternotomy site formed the keloid group, and 36 age- and sex-matched patients with no proliferative scar at the median sternotomy site formed the control group. Endothelial function was evaluated by flow-mediated vasodilatation of the brachial artery via ultrasonograhic examination.     Results: There is no signicant difference according to the demographic data, biochemical parameters, clinical parameters and number of grafts between keloid and control groups. Endothelial-dependent vasodilatory response was lower in the keloid group than the control group (9.30±3.5 and 18.68±8.2, respectively; p=0.001).     Conclusion: This study showed that endothalial dysfunction, which is strongly correlated with atherosclerosis, was more prominent in patients with proliferative scars. As proliferative scars and atherosclerosis have many features in common, we might conclude that atherosclerosis is a wound healing abnormality.
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UR  - https://dergipark.org.tr/en/pub/bmj/issue//501689
L1  - https://dergipark.org.tr/en/download/article-file/605249
ER  -