@article{article_503046, title={Synthesis of novel 8-formyl-7-hydroxy-4-methylcoumarin derivatives}, journal={Sakarya University Journal of Science}, volume={24}, pages={134–139}, year={2020}, DOI={10.16984/saufenbilder.503046}, author={Çelik Onar, Hülya and Erdoğan, Didem}, keywords={Schiff base,coumarin,Pechmann reaction,Duff reaction,6-amino-1,4-benzodioxane}, abstract={<p class="MsoNormal" style="text-align:justify;line-height:normal;"> <span style="font-family:’Times New Roman’, serif;">This study was initiated by
7-hydroxy-4-methylcoumarin <b>1 </b>
synthesis according to the Peckmann reaction with resorcinol and
ethylacetoacetate.  This compound was
converted into 8-formyl-7-hydroxy -4-methylcoumarin <b> <i> </i>2 </b>compound by the Duff
reaction.  This aldehyde obtained was
reacted with 6-amino-1,4-benzodioxane and 2-amino benzamide, which have their
specific biological activities, to synthesize the original two novel compounds.
While <b>3 </b>( <i>7-Hydroxy-4-methyl-8-[(2,3-dihidro-1,4-benzodioxin-6-yl)iminomethyl]-2H-1-benzopiran-2-on </i>)
is obtained as a coumarin schiff base, ring closure was  observed at <b>4 </b>( <i>2-(2’-Hydoxy-5-methyl
coumarin-1-yl)-2,3-dihidro quinazoline-4(1H)-on </i>). <span style="color:#222222;">Our
compounds are thought to exhibit biological activity. Their structures were
identified by IR, <sup>1 </sup>H NMR,  <sup>13 </sup>C
NMR , MS analysis. </span> </span> </p> <p> </p>}, number={1}, publisher={Sakarya University}