TY  - JOUR
T1  - Synthesis of novel  8-formyl-7-hydroxy-4-methylcoumarin derivatives
AU  - Çelik Onar, Hülya
AU  - Erdoğan, Didem
PY  - 2020
DA  - February
Y2  - 2019
DO  - 10.16984/saufenbilder.503046
JF  - Sakarya University Journal of Science
JO  - SAUJS
PB  - Sakarya University
WT  - DergiPark
SN  - 2147-835X
SP  - 134
EP  - 139
VL  - 24
IS  - 1
LA  - en
AB  - This study was initiated by7-hydroxy-4-methylcoumarin 1synthesis according to the Peckmann reaction with resorcinol andethylacetoacetate. This compound wasconverted into 8-formyl-7-hydroxy -4-methylcoumarin 2 compound by the Duffreaction. This aldehyde obtained wasreacted with 6-amino-1,4-benzodioxane and 2-amino benzamide, which have theirspecific biological activities, to synthesize the original two novel compounds.While 3 (7-Hydroxy-4-methyl-8-[(2,3-dihidro-1,4-benzodioxin-6-yl)iminomethyl]-2H-1-benzopiran-2-on)is obtained as a coumarin schiff base, ring closure was observed at 4 (2-(2’-Hydoxy-5-methylcoumarin-1-yl)-2,3-dihidro quinazoline-4(1H)-on). Ourcompounds are thought to exhibit biological activity. Their structures wereidentified by IR, 1H NMR, 13CNMR , MS analysis.
KW  - Schiff base
KW  - coumarin
KW  - Pechmann reaction
KW  - Duff reaction
KW  - 6-amino-1
KW  - 4-benzodioxane
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UR  - https://doi.org/10.16984/saufenbilder.503046
L1  - https://dergipark.org.tr/en/download/article-file/967507
ER  -