@article{article_504415, title={Serum apelin-36 levels in pre-diabetics and newly diagnosed diabetes mellitus patients}, journal={Cukurova Medical Journal}, volume={44}, pages={1094–1101}, year={2019}, DOI={10.17826/cumj.504415}, author={Yalçınkaya Kara, Zeynep Mine and Serin, Erdinç and Dağ, İsmail and Serin, Özden}, keywords={apelin 36,pre-diabetic,diabetes}, abstract={<p style="line-height:150%;"> <span style="font-size:12.6px;">Purpose: The aim of this study was to investigate the levels of parameters for glucose metabolism and cardiovascular risk factors and apelin-36 in patients grouped as having impaired fasting glucose(IFG), IFG and impaired glucose tolerance(IGT), newly diagnosed type 2 DM and the control group. </span> </p> <p style="line-height:150%;"> <span style="font-size:12.6px;">Materials and Methods: Fifty-three women and twenty-seven men, totally eighty subjects were enrolled in this study. The patients were classified into four groups according to their oral glucose tolerance test (OGTT) results. Group1: Normoglycemic controls(n:20), Group2: subjects with IFG(n:20), Group3: combined IFG subjects which included both IFG and IGT patients(n:20), Group4: Newly diagnosed type 2 DM patients(n:20). Levels of glucose, lipids, HbA1c, fibrinogen, insulin, cortisol, serum apelin-36 and C-peptide were analyzed. </span> </p> <p style="line-height:150%;"> <span style="font-size:12.6px;">Results: There was a statistically significant difference regarding the levels of apelin-36 between group 1 and the study groups 2, 3 and 4, respectively. Other parameters analyzed for glucose metabolism and cardiovascular risk factors such as fasting glucose, HbA1c, HOMA-IR, fibrinogen, insulin, cortisol, C-peptide, LDL-cholesterol, HDL-cholesterol, VLDL-cholesterol, triglycerides, total cholesterol were significantly higher in the study groups when compared to the control group. </span> </p> <p style="line-height:150%;"> <span style="font-size:12.6px;">Conclusion: In the future serum apelin-36 levels  can be used as an indicator for presenting the insulin resistance and impairment in glucose metabolism in the early periods. </span> </p> <div> <br /> </div> <p> </p>}, number={3}, publisher={Cukurova University}