@article{article_507568, title={Investigation of Bioactive Compounds on Relict Endemic Ajuga relicta P. H. Davis (Lamiaceae) from Turkey}, journal={International Journal of Secondary Metabolite}, volume={6}, pages={223–232}, year={2019}, DOI={10.21448/ijsm.507568}, author={Çömlekcioğlu, Nazan and Kocabaş, Yusuf Ziya and Aygan, Ashabil}, keywords={Ajuga relicta, antimicrobial, bioactive compounds, fatty acid, Relict-endemic}, abstract={<p class="normal" style="margin-bottom:.0001pt;text-align:justify;"> <span lang="ru" style="font-size:10pt;line-height:115%;font-family:’Times New Roman’, serif;" xml:lang="ru">Species belonging to genus <i>Ajuga </i>
(Lamiaceae) have been used to treat many diseases in traditional medicine.
The plants of the genus  <i>Ajuga </i> have
been reported to have antifungal, antibacterial, antimycobacterial, antihypertensive,
antiplasmodial, hypoglycaemic, and larvae and insect activity. <i>Ajuga relicta </i> is a relict endemic plant
which grows only in Kahramanmaras. The total phenolic contents of the extracts
have been quantified with Folin Ciocalteu colorimetric method, and the
antioxidant activities of the extracts have been tested with DPPH, and FRAP.
Antimicrobial activities of plant extracts were determined by the
well-diffusion method against seven bacteria and four yeasts. Besides, the
fatty acid composition was determined in GC-MS. As a result of GC-MS analysis
of the oil obtained from the <i>A. relicta </i>
extracts, 21 different fatty acids were identified. The highest contents of
these fatty acids were palmitic acid (29.50%), oleic acid (23.51%), stearic
acid (9.13%) and linoleic acid (7.18%). Total phenolic value of plant extract
was 11.94 mg/g, total flavonoid amount 2.28 mg/g, FRAP value 43.53 μg/g and
DPPH value 1.63 mg/g. Antimicrobial activity experiment on a total of 11
microorganisms (seven bacteria and four yeast) showed that <i>Ajuga </i> extracts inhibited the growth of tested microorganisms except <i>Enterobacter cloacae, Candida glabrata </i>
and <i>Saccharomyces cerevisiae </i>. </span> <span lang="ru" style="font-size:10pt;line-height:115%;font-family:’Open Sans’;" xml:lang="ru"> </span> <i> <span lang="ru" style="font-size:10pt;line-height:115%;font-family:’Times New Roman’, serif;" xml:lang="ru">A. relicta </span> </i> <span lang="ru" style="font-size:10pt;line-height:115%;font-family:’Times New Roman’, serif;" xml:lang="ru"> was
found to have high bioactive content and antimicrobial activity. The plant
extracts are rich in constant fatty acids and similar to olive oil
(palmitic-oleic-linoleic), which is well known for its health benefits in terms
of major fatty acids.  </span> <br /> </p> <p> </p>}, number={3}, publisher={İzzet KARA}