@article{article_511364, title={DOES SHILAJIT HAVE AN EFFECT ON NEW BONE REMODELLING IN THE RAPID MAXILLARY EXPANSION TREATMENT? A BIOCHEMICAL, HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY}, journal={Medical Journal of Süleyman Demirel University}, volume={26}, pages={96–103}, year={2019}, DOI={10.17343/sdutfd.511364}, author={Geçgelen Cesur, Mine and Ogrenim, Gozde and Gulle, Kanat and Sirin, Fevziye Burcu and Akpolat, Meryem and Cesur, Gokhan}, keywords={Rapid maxillary expansion, Shilajit, Relapse}, abstract={<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:200%;"> <span style="line-height:200%;">Aim: </span> <span style="line-height:200%;">The
aim of this study was to investigate the effects of shilajit on new bone
formation following rapid maxillary expansion (RME) in a rat study model using <span class="hps">biochemical, </span> histological, and immunohistochemical techniques. </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;line-height:200%;"> <span style="line-height:200%;">Material and Method: </span> <span class="hps"> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">The
rats ( </span> </span> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">12-week-old, 24
male Wistar albino </span> <span class="hps"> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">) were randomly divided into the following 3 groups
(n=8 each): no expansion (NE), only expansion (OE), expansion plus shilajit ( </span> </span> <span class="hps"> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">Shilajit </span> </span> <span class="hps"> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">). </span> </span> <span class="hps"> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">Shilajit </span> </span> <span class="hps"> <span lang="en-us" style="line-height:200%;" xml:lang="en-us"> was
given to the rats </span> </span> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">during the 5 day expansion and 12 day
retention period </span> <span class="hps"> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">. After sacrificing the animals, biochemical, </span> </span> <span style="line-height:200%;">histological, </span> <span class="hps"> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">and </span> </span> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">immunohistochemical </span> <span class="hps"> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">examinations were
performed. </span> </span> <span lang="en-us" style="line-height:200%;" xml:lang="en-us"> </span> </p> <p> </p> <p class="MsoNormal" style="line-height:200%;"> <span style="line-height:200%;">Results: </span> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">S </span> <span style="line-height:200%;">uperoxide
dismutase </span> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">, </span> <span style="line-height:200%;">catalase,
and glutathione peroxidase </span> <span class="st1"> <span style="line-height:200%;"> </span> </span> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">levels
in the shilajit group were statistically higher than the OE group (p<0.05). </span> <span style="line-height:200%;">Bone
alkaline phosphatase and C-telopeptide of type I collagen levels </span> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">demonstrated statistically significant differences
between the groups (p<0.001).  </span> <span style="line-height:200%;">The
immunohistochemical findings revealed that OE group had </span> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">significantly more </span> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">IL-1 and
TNF-α H scores than the shilajit group (p<0.05). </span> <span style="line-height:200%;">When
the groups were compared for </span> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">inflammatory
cell infiltration </span> <span style="line-height:200%;">, new bone formation, and capillary
intensity, considerable differences were found between the groups (p<0.05). </span> <span lang="en-us" style="line-height:200%;" xml:lang="en-us"> </span> </p> <p> </p> <p class="MsoNormal" align="center" style="text-align:center;line-height:200%;"> </p> <p class="MsoNormal" style="line-height:200%;"> <span style="line-height:200%;">Conclusion: </span> <span style="line-height:200%;">Systemic
use of shilajit may hasten new bone
formation in the midpalatal suture, which </span> <span lang="en-us" style="line-height:200%;" xml:lang="en-us">may be useful to prevent of relapse and shorten the
retention period after the RME treatment. </span> </p>}, number={1}, publisher={Süleyman Demirel University}