TY  - JOUR
T1  - OKSİDATİF STRES VE PARKİNSON HASTALIĞI
TT  - OXIDATIVE STRESS AND PARKINSON DISEASE
AU  - Aslan, Selma Nergis
AU  - Karahalil, Bensu
PY  - 2019
DA  - January
Y2  - 2019
DO  - 10.33483/jfpanu.519964
JF  - Journal of Faculty of Pharmacy of Ankara University
JO  - Ankara Ecz. Fak. Derg.
PB  - Ankara University
WT  - DergiPark
SN  - 1015-3918
SP  - 94
EP  - 116
VL  - 43
IS  - 1
LA  - tr
AB  - Amaç: Parkinson Hastalığı (PH) beyinde dopaminerjiknöronların kaybıyla ilişkili kronik ve progresif nörodejeneratif birhastalıktır. Yaşlılık tüm nörodejeneratif hastalıklarda olduğu gibi PH’nınoluşumunda da kanıtlanmış tek faktördür. Yaşlılıkta daha fazla tetiklenenoksidatif stresin dopaminerjik nörotoksisite oluşumunda önemli bir rol oynadığıdüşünülmektedir. Bu derlemede oksidatif stres ve PH arasındaki ilişkiirdelenecektir. Gereç ve Yöntem: PH ileoksidatif stres arasındaki ilişkinin tespiti için yapılmış çalışmalarınkapsamlı olarak derlenebilmesi için sağlık bilimleri alanındaki veri tabanlarıkullanılmıştır. Web of Science gibi temel atıf indekslerinde daha önceyayımlanmış makalelerden yararlanılmıştır.   Sonuç ve Tartışma: Parkinsonçok sayıda temel hücresel süreci etkileyen genetik ve çevresel faktörlerinkompleks etkileşiminden kaynaklanan nörodejeneratif bir hastalıktır. Oksidatifstres genetik bütünlüğü tehdit eder ve PH’nın gelişimine katkı sağlar.Oksidatif strese bağlı olarak meydana gelen hasar ürünlerinden kaçınmak ve buçizgide koruyucu tedavi protokolü çizmek sağlıklı beyin fonksiyonlarının devamıve organizmayı Parkinson gibi nörodejeneratif hastalıklardan korumak adına önemlibir strateji olabilir.
KW  - Parkinson hastalığı (PH)
KW  - oksidatif stres
KW  - reaktif oksijen türler (ROT)
KW  - yaşlanma
KW  - nörodejeneratif hastalık
N2  - Objective: Parkinson'sDisease (PD) is a chronic and progressive neurodegenerative disease in thebrain associated with the loss of dopaminergic neurons. Old age is the onlyproven factor in the development of PD. It is thought that oxidative stresswhich is more triggered in old age plays a vital role in the formation ofdopaminergic neurotoxicity. In this review, the relationship between oxidativestress and PD will be examined. Material and Method: The databases in the health sciences field wereused to compile the studies conducted to determine the relationship between PHand oxidative stress. Previously published articles such as Web of Science havebeen used. Result and Discussion: Parkinson's is a neurodegenerative diseaseresulting from the complex interaction of genetic and environmental factors thataffect on many basic cellular process. Oxidative stress threatens geneticintegrity and contributes to the development of PH. Avoidingdamage products due to oxidative stress and drawing a protective treatmentprotocol may be a crucial strategy for maintaining healthy brain function andprotecting the organism from neurodegenerative diseases such as Parkinson'sdisease.
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UR  - https://doi.org/10.33483/jfpanu.519964
L1  - https://dergipark.org.tr/en/download/article-file/637940
ER  -