@article{article_520248, title={Synthesis, characterization and antimicrobial studies of new chiral amide-Schiff base derivatives}, journal={Hacettepe Journal of Biology and Chemistry}, volume={48}, pages={33–39}, year={2020}, DOI={10.15671/hjbc.520248}, author={Yüksekdanacı, Seda and Astley, Demet and Yaşa, İhsan}, keywords={amino acid,amide,schiff base,antimicrobial}, abstract={<p class="MsoNormal" style="text-align:justify;"> <span style="font-size:9pt;">In this study, new chiral Schiff bases ( <b>3 </b>- <b>9 </b>) obtained from the reaction of chiral amide derivatives with different substituted aromatic aldehyde were synthesized. All synthesized compounds structures were characterized by FTIR, <sup>1 </sup>H-NMR, <sup>13 </sup>C-NMR and elemental analysis. All of the new synthesized compounds were tested in vitro against <i>Staphylococcus aureus, </i> <i>Bacillus cereus </i>, <i>Escherichia coli </i>, <i>Salmonella thyphimirium </i>, <i>Klebsiella pneumoniae </i>, <i>Enterococcus faecalis </i>, <i>Pseudomonas aeruginosa </i>, <i>Candida albicans </i> for their antibacterial and antifungal activities. All compounds have shown moderate to good antibacterial activity against Gram-positive and Gram-negative bacteria.  Among the compounds tested <b>compound 7 </b>showed most potent inhibitory action against test organisms. </span> </p> <p> </p>}, number={1}, publisher={Hacettepe University}