TY  - JOUR
T1  - PROBİYOTİK- İNSAN BAĞIŞIKLIK SİSTEMİ ETKİLEŞİMLERİ
TT  - PROBIOTIC-HUMAN IMMUNE SYSTEM INTERACTIONS
AU  - Kaplan Türköz, Burcu
AU  - Akpınar, Dicle Dilara
PY  - 2019
DA  - October
DO  - 10.3153/FH19027
JF  - Food and Health
JO  - Food Health
PB  - Özkan ÖZDEN
WT  - DergiPark
SN  - 2602-2834
SP  - 265
EP  - 280
VL  - 5
IS  - 4
LA  - tr
AB  - Probiyotikleryeterli miktarda tüketildiklerinde sağlık üzerine yararlı etkiler gösterencanlı mikroorganizmalardır. Bu mikroorganizmalar, patojenlerle mücadele, epitelhücre kararlılığını sağlama ve bağışıklık sistemini düzenleyebilmeleri ilesağlık üzerine olumlu etkiler göstermektedirler. Bağışıklık düzenleyici,anti-inflamatuar, anti-mikrobiyal, anti-oksidan etkilerini, açığa çıkardıklarımetabolitleriyle, ürettikleri moleküllerle ve hücre yapı bileşenleriylesağlamaktadırlar. Peptidoglikan, teikoik asit, lipoteikoik asit, hücre yüzeypolisakkaritleri, salgılanan proteinler ve yüzey proteinleri gibi probiyotiketken molekülleri doğal bağışıklıkta görevli reseptörler tarafından tanınarakbağışıklık sistemini harekete geçirmektedir. Yapılan çalışmalarla bu etkenmoleküllerinden bazılarının etki mekanizmaları aydınlatılmıştır.Bu derlemedeprobiyotiklerin, probiyotik-konak etkileşimleri için kullandıkları bilinenetken molekülleri hakkında ve etkileri üzerine bilgi verilmesi amaçlanmıştır.
KW  - Probiyotikler
KW  - Sağlık etkileri
KW  - Probiyotik-konak etkileşimleri
KW  - Bağışıklık düzenleme
KW  - Etken moleküller
N2  - Probiotics arelive microorganisms which when administered in adequate amounts confer a healthbenefit on the host. These microorganisms are known to provide beneficialhealth effects by competing with pathogens, providing epithelial cell stabilityand showing regulatory effects on the immune system. They provideimmunomodulatory, anti-inflammatory, anti-microbial, antioxidant effects withtheir released metabolites, produced molecules and cell structure components.Effector molecules of probiotics such as peptidoglycan, teichoic acid,lipoteichoic acid, cell surface polysaccharides, secreted proteins and surfaceproteins are recognized by innate immunity receptors and activate the immunesystem. The mechanisms of some effector molecules of probiotics have beenelucidated. The aim of this review is to give information on the effects ofprobiotics and their active molecules known to be used for probiotic-hostinteractions.
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UR  - https://doi.org/10.3153/FH19027
L1  - https://dergipark.org.tr/en/download/article-file/800122
ER  -