@article{article_525924, title={Nephroprotective and antioxidative effects of royal jelly on ethylene glycol induced nephropathy in rats}, journal={Ankara Üniversitesi Veteriner Fakültesi Dergisi}, volume={64}, pages={241–248}, year={2017}, DOI={10.1501/Vetfak_0000002805}, url={https://izlik.org/JA82DE23TX}, author={Aksoy, Laçine and Aslan, Zeyneb}, keywords={Antioxidant, calcium oxalate, ethylene glycol, nephropathy, royal jelly}, abstract={Antioxidative and nephroprotective effects of royal jelly against ethylene glycol induced renal injury were examined in this study. Five groups of rats were used. Rats in Group 1 served as control. Rats in Group 2 received ethylene glycol (1%) in drinking water, while those in Group 3 received 100 mg/kg of royal jelly through oral gavage. Group 4 served as protective group and received ethylene glycol 1% in drinking water and 100 mg/kg of royal jelly administered. Group 5 served as treatment group and received ethylene glycol 1% in the drinking water for the initial 15 days, followed by 100 mg/kg of royal jelly administered last 15 days. Oxidative stress was induced by ethylene glycol. Royal jelly was found to reduce renal damage with measured BUN and CREA (creatinine) levels. It was considered that royal jelly has positive effects on antioxidant system and decreased effects on lipid peroxidation. Royal jelly may have positive nephroprotective effects on the injury induced by ethylene glycol exposure. Particularly, the effects observed in the treatment group were remarkable.}, number={4}