TY  - JOUR
T1  - Çölyak hastalarında ve sağlıklı çocuklarda laktoz malabsorbsiyonu
TT  - Lactose malabsorption in children with celiac disease and healthy children
AU  - Comba, Atakan
AU  - Demirbaş, Fatma
AU  - Eren, Esra
AU  - Çaltepe, Gönül
AU  - Yüce, Özlem
AU  - Kalaycı, Ayhan Gazi
PY  - 2019
DA  - May
Y2  - 2019
DO  - 10.31362/patd.531821
JF  - Pamukkale Medical Journal
JO  - Pam Med J
PB  - Pamukkale University
WT  - DergiPark
SN  - 1308-0865
SP  - 321
EP  - 328
VL  - 12
IS  - 2
LA  - tr
AB  - Amaç Laktoz malabsorbsiyonu, doğuştan, primer veyasekonder olarak ortaya çıkabilir. Çölyak hastalığı, sekonder laktozmalabsorbsiyona neden olan birhastalıktır. Bu çalışmada, çölyak hastası çocuklar ile sağlıklıçocuklarda laktoz hidrojen nefes testi ile laktoz malabsorbsiyon sıklığınınbelirlenmesi amaçlanmıştır.Gereçve Yöntem Çalışmaya, 64 çölyakhastası ve 52 sağlıklı çocuk dahil edildi. Çölyak hastaları yeni tanı alanlarve takipli çölyak hastaları olarak iki gruba ayrıldı. Takipli çölyak hastaları tedaviye(glutensiz diyete) tam uyumlu olanlar ve tedaviye uyumsuz olanlar olarak ikigrupta incelendi. Laktoz hidrojen nefes testi 0-500 ppm hidrojen seviyesinialgılayabilen ve 1 ppm düzeyinde duyarlı gaz analiz cihazı kullanılarakyapıldı. BulgularÇocukların ortalama yaşı 10,4 ±4,5 yıldı. Çölyak hastalarının 16’sıyeni tanılı, 48’i takipli idi. Takipli çölyakların 24’ü (%50) glutensiz diyetetam uyumluydu. Yeni tanı çölyak hastalarının %62,5’inde, glutensiz diyeteuyumsuz olanların %54,2’sinde, glutensiz diyete tam uyumluların %33,3’ünde,sağlıklı çocukların ise %19,2’sinde laktoz hidrojen nefes testi pozitifti. Yenitanılı ve glutensiz diyete uymayan çölyak hastalarının laktoz hidrojen nefestesti pozitiflik oranı (sırasıyla, %62,5; %54,2), sağlıklı çocuklardan (%19,2)anlamlı olarak yüksekti (sırasıyla, p=0,002ve p=0,003). Hem çölyak hastalarındahem de sağlıklı çocuklarda, laktoz hidrojen nefes testi pozitif olanların bedenkitle indeksi z skoru, negatif olan çocuklardan anlamlı olarak düşüktü (p<0,001,p=0,041; sırasıyla).SonuçÇalışmada, çölyak serolojisi pozitif olan hastalarda laktoz hidrojen nefestesti pozitifliği anlamlı olarak yüksek bulundu. Çölyak hastalığında laktozhidrojen nefes testi ile laktoz malabsorbsiyon sıklığı ve mukozal hasarindirekt olarak saptanabilir. Laktoz malabsorbsiyonu, beden kitle indeksi düşükolan çocuklarda daha sık görülmektedir.
KW  - çocuk
KW  - çölyak hastalığı
KW  - hidrojen nefes testi
KW  - laktoz malabsorbsiyonu
N2  - Purpose.Lactose malabsorption(LM) can be congenital, primary, or secondary. Celiacdisease (CD) is a secondary cause of lactose malabsorption. This study aimed todetermine lactose malabsorption frequency using a lactose hydrogen breath test(LHBT) in children with celiac disease and healthy children. Materials and methods.The study included 64 children with CD and 52 healthy controls. Celiac patients were dividedinto groups as newly diagnosed and followed celiac patients. The latter weredivided into groups as compliance or noncompliance with gluten-free diet (GFD).LHBT was performed using a gas analyser with a1-ppm sensor sensitivity of hydrogen levels of 0–500 ppm.Results.Mean age of thechildren was 10.4 ± 4.5 years. Sixteen of the patients had newly diagnosedceliac disease, and 24 (50%) were compliant with GFD. LHBT results were positive in 62.5% of the newly diagnosed CDpatients, 33.3% of those compliant with GFD,54.2% of those non-compliant with GFD,and 19.2% of controls. Asignificantly higher proportion of newly diagnosed CD (62.5%) and non-compliantwith GFD (54.2%) had positive LHBTresults than controls (19.2%) (p=0.002and p=0.003, respectively). The body mass index z scores of the childrenwith LHBT positivity were significantly lower than others in both healthychildren and children with CD (p<0.001,p=0.041, respectively).Conclusion.In our study, the frequency of LHBT positivity was significantly higher inceliac patients with positive celiac serology.LHBTidentified mucosal damage as indirect in celiac disease. Lactose malabsorptionis more common in children who have low body mass index.
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UR  - https://doi.org/10.31362/patd.531821
L1  - https://dergipark.org.tr/en/download/article-file/725442
ER  -