TY  - JOUR
T1  - Oreochromis niloticus'un Karaciğerinde Fungisit Propiconazole'un Oksidatif Stres Parametreleri ve Antioksidan Sistem Enzimleri Üzerine Etkileri
TT  - Effects of Fungicide Propiconazole on Oxidative Stress Parameters and Antioxidant System enzymes in liver of Oreochromis niloticus
AU  - Temiz, Ozge
PY  - 2019
DA  - April
Y2  - 2019
DO  - 10.35229/jaes.532079
JF  - Journal of Anatolian Environmental and Animal Sciences
JO  - JAES
PB  - Bülent VEREP
WT  - DergiPark
SN  - 2548-0006
SP  - 43
EP  - 47
VL  - 4
IS  - 1
LA  - tr
AB  - BuAraştırmada, fungisit propiconazole’un 0.5 ppb ve 2.5 ppb derişim etkilerinde 7gün ve 28 gün sürelerde Oreochromisniloticus’un karaciğer dokusunda, süperoksit dismutaz (SOD), katalaz (CAT),glutatyon peroksidaz (GPx) ve glutatyon S transferaz (GST) antioksidan sistemenzim aktiviteleri ve oksidatif stres parametreleri glutatyon (GSH) vetiyobarbitürik asit reaktif maddeleri (TBARS) miktarlarındaki değişimlerspektrofotometrik yöntemlerle belirlenmiştir. Çalışmamızdakaraciğer dokusunda GSH miktarı ve GSH-bağımlı GPx ve GST aktivitesi 7. gündeartarken; 28. günde GSH miktarında azalma ve GST aktivitelerinde artışbelirlenmiştir. SOD ve CAT aktiviteleri 7. günde artarken 28. günde azalmıştır.TBARS düzeylerinde propiconazole etkisinde süreye ve derişime bağlı olarakartış göstermektedir.Çalışmasonuçlarına göre propiconazole etkisinde O.niloticus’da antioksidan sistem enzim aktivitelerinde ve oksidatif stresparametrelerindeki değişimler propiconazole’un hepatotoksik etkiye neden olduğubelirlenmiştir.
KW  - Fungisit
KW  - Propiconazole
KW  - Oreochromis niloticus
KW  - Karaciğer
KW  - Antioksidan sistem
KW  - Glutatyon
N2  - Inthis research, 0.5 ppb and 2.5 ppb effect of fungicide propiconazole in 7 daysand 28 days periods in liver tissue of Oreochromisniloticus, superoxide dismutase (SOD), catalase (CAT), glutathioneperoxidase (GPx) and glutathione Stransferase (GST) antioxidant system enzyme activities and oxidative stressparameters glutathione (GSH) and thiobarbituric acid reagents (TBARS) weredetermined by spectrophotometric methods.Inour study, GSH levels and GSH-dependent GPx and GST activity increased in 7days. In 28 days, decrease in GSH and increase in GST activities weredetermined. SOD and CAT activities increased in 7 days and decreased in 28days. In TBARS levels, the time and concentrations -related increase in theeffect of propiconazole Accordingto the results of the study; The effect of propiconazole on antioxidant enzymeactivity and oxidative stress parameters in O.niloticus was determined to cause hepatotoxic effect.
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UR  - https://doi.org/10.35229/jaes.532079
L1  - https://dergipark.org.tr/en/download/article-file/691885
ER  -