TY  - JOUR
T1  - Serum Cardiac Troponin-I in dogs with CPV-2 infection
TT  - CPV-2 infeksiyonlu köpeklerde Serum Kardiyak Troponin-I
AU  - Bastan, İdil
AU  - Kurtdede, Arif
AU  - Sel, Tevhide
AU  - Özen, Doğukan
AU  - Yumuşak, Nihat
AU  - Tımurkan, M. Özkan
AU  - Baydın, Ahmet
PY  - 2013
DA  - December
DO  - 10.1501/Vetfak_0000002588
JF  - Ankara Üniversitesi Veteriner Fakültesi Dergisi
JO  - Ankara Univ Vet Fak Derg
PB  - Ankara University
WT  - DergiPark
SN  - 1300-0861
SP  - 251
EP  - 255
VL  - 60
IS  - 4
LA  - en
AB  - The objective of study was to determine the clinical significance of serum cTn-I level in dogs infected with Canine parvovirus-2 (CPV-2). The study material consisted of 4- to 10-week-old puppies of either sexes and 8 different breeds of twenty five dogs with CPV-2. Control group consisted of 4- to 10-week-old puppies of either sexes and 7 different breeds of twenty five dogs. Although treatment, 12 of the dogs with serum cTn-I level > 0.8 ng/mL died within 24 hours of admission. Remaining 13 dogs, had the serum cTn-I level <0.156 ng/mL (cut-off). Of 13 dogs, 4 died within 24-72 hours of admission and 9 were recovered. In terms of cTn-I concentration, whether below 0.156 ng/mL or above 0.8 ng/mL there was a statistically significant difference between survivor and non-survivor animals (p<0.001). Construction of Kaplan-Meier, survival curves revealed dogs with a cTn-I concentration > 0.8 ng/mL had survival time of 1 day, whereas dogs with a cTn-I concentration <0.156 ng/mL had a median survival time of 2.5 days (p<0,001). No statistically significant difference was determined between the mean ages of two groups (dogs with cTn-I concentration <0.156 and > 0.8 ng/mL) (p>0.05). At necropsy, the histopathological examination of the heart revealed the presence of pathological myocarditis findings in 12 of the non-survivor dogs (cTn-I > 0.8 ng/mL), whilst in the other non-survivor 4 dogs (cTn-I<0.156), no pathological alteration was observed in the myocardium. The present study demonstrated that serum cTn-I concentrations > 0.8 ng/mL were indicators of poor prognosis and increased serum cTn-I concentrations were consistent with short survival times in dogs with CPV-2
KW  - Canine parvovirus
KW  - cardiac troponin I
KW  - myocarditis
N2  - Bu çalışmada, CPV-2’li köpeklerde cTn-I konsantrasyonunun klinik öneminin değerlendirilmesi amaçlandı. Çalışmanın materyalini değişik ırk ve her iki cinsiyetten 4-10 haftalık yaşta 25’i hasta ve 25’i sağlıklı olmak üzere 50 yavru köpek oluşturdu. Sağaltım uygulamasının başlatılmasına rağmen serum cTn-I konsantrasyonu > 0.8 ng/mL olan hasta köpeklerin 12’si kliniğe getirildikten sonraki 24 saat içinde öldü. Kliniğe getirildikten sonra 24-72. saatlerde ölen 4 köpek ile sağaltım sonucu iyileşen 9 köpekte cTn-I konsantrasyonları <0.156 ng/mL (cut-off değeri) bulundu. Sağlıklı köpeklerde serum cTn-I konsantrasyonu 0,156 ng/ml değerinin (cut-off) altında saptandı. CTn-I konsantrasyonu karşılaştırıldığında ölen ve iyileşen köpekler arasında önemli farklılık saptandı (p<0.001). Serum cTn-I konsanrasyonu> 0.8 ng/mL olan köpeklerde yaşam zamanı 1 gün iken cTn-I konsantrasyonı <0.156 ng/mL olan köpeklerde ortalama yaşam süresi 2.5 gün (p<0,001) olarak hesaplandı.Serum cTn-I konsantrasyonu açısından değerlendirildiğinde yaş ortalamaları arasında istatiksel olarak önemli bir farklılık bulunmadı (p>0.05). Ölen 12 köpeğin (cTn-I > 0.8 ng/mL) nekropsisinde kalbin histopatolojik incelemesinde myokarditise bağlı patolojik değişiklikler belirlenirken ölen diğer 4 köpekte (cTn-I<0.156) kalp kasında herhangi bir patolojik değişikliğe rastlanmadı. Sonuç olarak bu çalışma serum cTn-I konsantrasyonunun 0.8 ng/mL’ nin üstünde olması kötü prognozun belirleyicisi olduğunu ve yüksek serum cTnI konsantrasyonu ile kısa yaşam süresi arasında ilişki olduğunu gösterdi
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UR  - https://doi.org/10.1501/Vetfak_0000002588
L1  - https://dergipark.org.tr/en/download/article-file/659361
ER  -