TY  - JOUR
TT  - Pulmonary hamartoma: Retrospective analysis of 24 cases
AU  - Dikis, Ozlem Sengoren
AU  - Haberal, Miktat Arif
AU  - Akar, Erkan
PY  - 2019
DA  - March
DO  - 10.5798/dicletip.534820
JF  - Dicle Medical Journal
JO  - diclemedj
PB  - Dicle University
WT  - DergiPark
SN  - 1300-2945
SP  - 27
EP  - 32
VL  - 46
IS  - 1
LA  - en
KW  - surgical resection
KW  - hamartoma
N2  - Objective:Lung hamartoma is the most frequently diagnosed benign lung tumor. The aim ofthis study was to investigate the clinical, radiological and pathological dataof the patients with pulmonary hamartoma who underwent surgical treatment inour clinic.Methods: Hospitalrecords of 24 lung hamartoma patients given surgical treatment in our clinicsbetween January 2005 and December 2017 were investigated retrospectively. Inthis study, these cases were evaluated with respect to age, gender, clinical,histopathological, and radiological features, and surgical methods.Results: Therewere 24 patients with a mean age of 50.6 (23-66) years, consisting of 14 malesand 10 females, who underwent surgical resection for pulmonary hamartoma was.While 17 (42%) patients were asymptomatic, the rest complained of coughing,shortness of breath and repetitive lung infections. Hamartoma was localized inthe right lung in 16 (67%) of the cases; peripherally in 17 (71%), andcentrally in 7 (29%). All patients underwent wedge resection, 17 cases bythoracoscopy and 7 cases by thoracotomy. The mean tumor diameter assessedmacroscopically was 2.9 cm (1-4.5cm).Conclusion:Pulmonary hamartomas frequently present as peripheral solitary nodules. Givenits low morbidity and mortality, surgical resection is recommended fordefinitive diagnosis and treatment, the objective of the intervention beingtotal excision of the lesion while protecting the lung parenchyma.
CR  - 1. Özlü T,Metintaş M,Kaya A. Solunum sistemi ve hastalıkları Temel başvuru kitabı.Cilt 2. (Respiratory system and its diseases – Reference book, Volume 2): Istanbul Medikal Yayıncılık 2010; 1511-12.
CR  - 2. Okudela K, Umeda S, Otara M, et all. A case of pulmonary hamartoma with distinctive histopathological features: a discussion of its differential diagnosis and histogenesis. Pathol Int 2014; 64: 618-23.
CR  - 3. Suut S, Al-Ani Z, Allen C, et all. Pictorial essay of radiological features of benign intrathoracic masses. Ann Thorac Med. 2015 Oct-Dec; 10: 231-42.
CR  - 4. Ekinci GH, Hacıömeroğlu O, Ersev A, et all. The frequency of lung cancer in patients with pulmonary hamartomas: An evaluation of clinical, radiological, and pathological features and follow-up data of 96 patients with pulmonary hamartomas. Rev Port Pneumol. 2017 Sep - Oct; 23: 280-6.
CR  - 5. An J, Long M, Jiang Y, Jin Y. Concomitant a giant pulmonary bulla on the left lower lobe and hamartoma successfully treated by video-assisted thoracoscopic pulmonary wedge resection. AME Case Rep. 2017 Sep 26; 1: 2.
CR  - 6. Abdel Hady SM, Elbastawisy SE, Hassaballa AS, Elsayed HH. Is surgical resection superior to bronchoscopic resection in patients with symptomatic endobronchial hamartoma? Interact Cardiovasc Thorac Surg. 2017 May 1; 24: 778-82.
CR  - 7. Dimitrakakis G, Challoumas D, Rama Rao Podila S, et all. The challenge of pulmonary endobronchial chondromatous hamartomas.J BUON. 2014 Jan-Mar; 19: 60-5.
CR  - 8. Elsayed H, Abdel Hady SM, Elbastawisy SE. Is resection necessary in biopsy-proven asymptomatic pulmonary hamartomas? Interact Cardiovasc Thorac Surg. 2015 Dec; 21: 773-6.
CR  - 9. Siegelman SS, Khouri NF, Scott WW, et all. Pulmonary hamartoma: CT findings. Radiology 1986; 160: 313-7.
CR  - 10. Oldham HN Jr, Young WG Jr, Sealy WC. Hamartoma of the lung. J Thorac Cardiovasc Surg 1967; 53: 735-42.
CR  - 11. Ledor K, Fish B, Chaise L, Ledor S. CT diagnosis of pulmonary hamartomas. J Comput Assist Tomogr 1981; 5: 343-4.
CR  - 12. 9-Zehani-Kassar A, Ayadi-Kaddour A, Marghli A, et all. Clinical characteristics of resected bronchial hamartoma. Study of seven cases.Rev Mal Respir. 2011 May; 28: 647-53. 2011 Apr 16.
CR  - 13. Asad S, Aquino SL, Piyavisetpat N, Fischman AJ. False-positive FDG positron emission tomography uptake in nonmalignant chest abnormalities. AJR Am J Roentgenol 2004; 182: 983–9.
CR  - 14. ChristensenJA ,Nathan MA, Mullan BP, et all. Characterization of the solitary pulmonary nodule: 18F-FDG PET versus nodule-enhancement CT. AJR Am J Roentgenol2006; 187: 1361–7.
CR  - 15. De Cicco C, Bellomi M, Bartolomei M, et all. Imaging of lung hamartomas by multidetector computed tomography and positron emission tomography. Ann Thorac Surg 2008; 86: 1769–72.
CR  - 16. Settas N, Faucz FR, Stratakis CA. Succinate dehydrogenase (SDH) deficiency, Carney triad and the epigenome. Mol Cell Endocrinol. 2018 Jul 5; 469: 107-11.
CR  - 17. Boikos SA, Xekouki P, Fumagalli E, et all. Carney triad can be (rarely) associated with germline succinate dehydrogenase defects. Eur J Hum Genet 2016; 24: 569–73.
CR  - 18. Garofola C, Gross GP. Hamartoma, Cowden Disease (Multiple Hamartoma Syndrome). Stat Pearls TreasureIsland(FL):StatPearlsPublishing;2018-.2018 Oct 27.
CR  - 19. Leiter Herrán F, Restrepo CS, Alvarez Gómez DI, et all. Hamartomas from head to toe: an imaging overview. Br J Radiol. 2017 Mar; 90 (1071): 20160607.
CR  - 20. von Ranke FM, Zanetti G, e Silva JL, et all. Tuberous sclerosis complex: state-of-the-art review with a focus on pulmonary involvement. Lung 2015; 193: 619–27.
CR  - 21. Xia Y, Wang KP.Transbronchial needle aspiration: where are we now? J Thorac Dis. 2013 Oct; 5: 678-82.
CR  - 22. Klein JS. Transthoracic needle aspiration biopsy for the cytologic diagnosis of subsolid lung nodules. Cancer Cytopathol. 2016 Jul; 124: 451-2.
CR  - 23. Serkan Bayram, Çağatay Tezel, Serdar Evman, ve ark. Sol ana bronş tümörüne sağ torakotomi ile izole sleeve rezeksiyon. Dicle Tıp Dergisi / Dicle Medical Journal 2017; 44: 119–23.
UR  - https://doi.org/10.5798/dicletip.534820
L1  - https://dergipark.org.tr/en/download/article-file/662142
ER  -