@article{article_540270, title={The Investigation of The Factors Affecting Retroperitoneal Lymph Node Metastasis In Epithelial Ovarian Cancer}, journal={Türk Jinekolojik Onkoloji Dergisi}, volume={20}, pages={13–22}, year={2019}, author={Dağdeviren, Hediye and Tekirdağ, Ali İsmet and Akbayır, Özgür}, keywords={Ovarian cancer,Lymph node,Metastasis}, abstract={<p>Objective: In this study, the factors associated with lymph node involvement in patients with epithelial ovarian cancer were investigated. One of the major spreading ways of ovarian cancer is lymphatic spread. This type of spread is often seen in advanced stages. Therefore, it is essential to determine the factors aff ecting lymph node involvement in ovarian cancer and to develop new treatment methods for these factors. Material and Method: In our study, the ovarian cancer cases who were admitted to Bakırköy Gynecology and Pediatrics Education Research Hospital and operated in the last 10 years were evaluated and clinical and pathological factors in terms of possible lymph node involvement in a single-centered and homogeneous patient group were investigated. Results: Accordingly, pre-operative CA-125 protein levels were signifi cantly determined lower in patients with negative lymph node (469 ± 954) than those with positive lymph node (1307 ± 2937) (p = 0.004 <0.05). In addition, a statistically signifi cant relationship was detected between CA-125 value and the surgical stage of the disease and lymph node involvement was determined to be increased with the increase in CA-125 level (p <0.04). Besides, a positive relationship was determined between high preoperative CA-125 levels and omentum involvement and lymph node involvement, but no relationship was found between tumor histology and grade and lymph node involvement. Conclusion: In the light of the fi ndings obtained from the study; it was detected that the presence of lymphatic involvement in epithelial ovarian cancer was important for 5-year survival and that there was a positive correlation between the stage increase and lymphatic involvement. The histopathological and molecular eff ects of factors aff ecting lymph node involvement can be enlightened by a large series of studies in which all risk factors in this regard are evaluated together.  <br> </p>}, number={2}, publisher={Türk Jinekolojik Onkoloji Derneği}