@article{article_541829, title={The Protective Effect of Melatonin on Plasma Lipid Profile in Rats with Cerulein-induced Acute Pancreatitis}, journal={Turkish Journal of Sport and Exercise}, volume={21}, pages={332–336}, year={2019}, DOI={10.15314/tsed.541829}, author={Keskin, Ercan and Uluışık, Deniz}, keywords={Cerulein,melatonin,acute pancreatitis,lipid profile}, abstract={<div style="text-align:justify;"> <span lang="en-us" xml:lang="en-us" style="font-size:10px;line-height:115%;font-family:’Times New Roman’, serif;">ABSTRACT </span> </div> <div style="text-align:justify;"> <span lang="en-us" xml:lang="en-us" style="font-size:10px;line-height:115%;font-family:’Times New Roman’, serif;">The objective of this study was to assessment
the effect of melatonin on lipid profile in rats with experimentally induced
acute pancreatitis. </span> <span lang="en-us" xml:lang="en-us" style="font-size:10px;line-height:115%;font-family:’Times New Roman’, serif;">In this study, 32 adult, male, healthy Wistar Abino rats were
used. </span> <span lang="en-us" xml:lang="en-us" style="font-size:10px;line-height:115%;font-family:’Times New Roman’, serif;">Group I animals was no applied.
Group II animals was intraperitoneally administered </span> <span lang="en-us" xml:lang="en-us" style="font-size:10px;line-height:115%;font-family:’Times New Roman’, serif;">50 mg/kg melatonin
per rat twice for two hours intervals. Animals
of group III received two intraperitoneal injections of cerulein (50 µg/kg and
25 µg/kg bw, respectively) at two hours
intervals. Animals of group IV
received two intraperitoneal injections of cerulein (50 µg/kg and 25 µg/kg bw,
respectively) at two hours intervals and
the rats received an intraperitoneal injection of 50 mg/kg melatonin 30 min
before each cerulein injection. After 12
hours from the last cerulein injection, </span> <span lang="en-us" xml:lang="en-us" style="font-size:10px;line-height:115%;font-family:’Times New Roman’, serif;">total cholesterol, triglyceride, LDL, HDL
levels was determined. </span> <span lang="en-us" xml:lang="en-us" style="font-size:10px;line-height:115%;font-family:’Times New Roman’, serif;"> In this study,
experimentally induced acute pancreatitis resulted in significantly increase in
levels of total cholesterol, triglyceride and LDL </span> <span lang="en-us" xml:lang="en-us" style="font-size:10px;line-height:115%;font-family:’Times New Roman’, serif;">(p<0.05) </span> <span lang="en-us" xml:lang="en-us" style="font-size:10px;line-height:115%;font-family:’Times New Roman’, serif;">, while HDL level
significantly decreased compared with control group level </span> <span lang="en-us" xml:lang="en-us" style="font-size:10px;line-height:115%;font-family:’Times New Roman’, serif;">(p<0.05) </span> <span lang="en-us" xml:lang="en-us" style="font-size:10px;line-height:115%;font-family:’Times New Roman’, serif;">. Pretreatment of melatonin
to the rats with acute pancreatitis importantly reduced triglyceride and LDL
levels compared to pancreatitis group </span> <span lang="en-us" xml:lang="en-us" style="font-size:10px;line-height:115%;font-family:’Times New Roman’, serif;">(p<0.05) </span> <span lang="en-us" xml:lang="en-us" style="font-size:10px;line-height:115%;font-family:’Times New Roman’, serif;">. In conclusion, melatonin pretreatment may alleviate
the abnormalities in plasma lipid profile caused by acute pancreatitis. </span> </div>}, number={2}, publisher={Selcuk University}