@article{article_542120, title={A Hybrid Approach for Large-scale Fabrication of Paper-based Electrochemical Assays for Biomedical Diagnosis}, journal={Celal Bayar University Journal of Science}, volume={15}, pages={271–277}, year={2019}, DOI={10.18466/cbayarfbe.542120}, author={Ghaderinezhad, Fariba and Tasoglu, Savas}, keywords={pen plotter,paper-based assays,electrochemical,glucose assay,high-throughput,biosensor}, abstract={<h4 style="text-align:justify;padding:5px;font-family:Cambria;font-size:20px;line-height:16px;margin:0px;color:rgb(0,0,0);"> <span lang="en-us" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-us">The electrochemical method offers a sensitive, portable, and
cost-effective method for detecting a range of analytes and has the capacity to
be miniaturized. However, according to the World Health Organization, there is
a need for point-of-care devices that meet the criteria for medical diagnostics
in remote and resource-limited regions, as set forth by the World Health
Organization. In this context, we developed a low-cost and high-throughput
method for fabricating paper-based devices for electrochemical assays using a
desktop pen plotter. In this study, we used a permanent marker to plot
hydrophobic barriers and a liquid dispenser to pattern three electrodes
(working, counter, and reference electrodes) with carbon paste on a paper
substrate. To test the performance of the fabricated electrochemical devices,
chronoamperometric and cyclic voltammetric analyses of potassium ferricyanide
was conducted. Further, to demonstrate of the possible biomedical diagnostic
applications, a quantitative glucose assay was performed. Here, we presented a
low-cost electrochemical device fabrication method convenient for large-scale
fabrication and widespread implementation of paper-based technologies in
developing countries and resource-limited settings. </span> <br /> </h4>}, number={3}, publisher={Manisa Celal Bayar University}