@article{article_544201, title={The evaluation of retinal nerve fiber layer thickness in subjects with insulin resistance}, journal={Pamukkale Medical Journal}, volume={12}, pages={503–508}, year={2019}, DOI={10.31362/patd.544201}, author={Uzun, Feyzahan and Fındık, Hüseyin and Beyazal Polat, Hatice}, keywords={Diabetes mellitus,insulin resistance,optical coherence tomography}, abstract={<p class="MsoNormal" style="line-height:150%;"> <b> <span style="font-size:12pt;line-height:150%;font-family:Arial, sans-serif;">Purpose: </span> </b> <span style="font-size:12pt;line-height:150%;font-family:Arial, sans-serif;"> To measure <b> </b>the retinal nerve fiber layer
thickness (RNFLT) in prediabetic subjects who were diagnosed with insulin
resistance and to compare with healthy controls. </span> </p> <p> </p> <p class="MsoNormal" style="line-height:150%;"> <b> <span style="font-size:12pt;line-height:150%;font-family:Arial, sans-serif;">Materials
and methods: </span> </b> <span style="font-size:12pt;line-height:150%;font-family:Arial, sans-serif;"> </span> <span style="font-size:12pt;line-height:150%;font-family:Arial, sans-serif;">Each
subject was underwent a standard ophthalmological examination including measurement
of best corrected visual acuity and intraocular pressure, anterior segment
biomicroscopy and funduscopy. Average and four quadrant (superior, temporal,
inferior, nasal) RNFLT measurements were performed using spectral domain
optical coherence tomography (OCT). Plasma fasting insulin and glucose levels
were noted and homeostasis model assessment of insulin resistance index
(HOMA-IR) was calculated. </span> </p> <p> </p> <p class="MsoNormal" style="line-height:150%;"> <b> <span style="font-size:12pt;line-height:150%;font-family:Arial, sans-serif;">Results: </span> </b> <span style="font-size:12pt;line-height:150%;font-family:Arial, sans-serif;"> A
total of 37 patients with insulin resistance and 41 healthy controls were
included in the study. Mean age of the insulin resistant group and healthy
controls were 35.7±9.8 and 34.9±10.7 years, respectively. <a>The average (95.03±11.38 µm <i>vs </i>99.2±19.73 µm), inferior (119.11±18.27 µm <i>vs </i>127.5±21.03 µm) and temporal (72.13±12.52 µm <i> vs </i> 79.2±15.97 µm)  quadrant
RNFL were significantly thinner in subjects with insulin resistance as compared
with healthy controls </a>(p<0.05). No significant difference was observed
between the groups in the superior (121.01±9 µm <i> vs </i> 123.9±01 µm) and nasal (72.03±13.65 µm <i>vs </i> 74.52±10.52 µm) quadrants (p˃0.05). </span> </p> <p> </p> <p> </p> <p class="MsoNormal" style="line-height:150%;"> <b> <span style="font-size:12pt;line-height:150%;font-family:Arial, sans-serif;">Conclusion: </span> </b> <span style="font-size:12pt;line-height:150%;font-family:Arial, sans-serif;"> Neurodegeneration
of the retina which is seen in diabetic patients may begin in the insulin
resistance stage. OCT is a useful tool both in the early diagnosis and
follow-up of retinal neurodegeneration. </span> </p> <p> </p>}, number={3}, publisher={Pamukkale University}