TY  - JOUR
T1  - The evaluation of retinal nerve fiber layer thickness in subjects with insulin resistance
TT  - İnsülin rezistansı bulunan bireylerde retina sinir lifi tabakası kalınlığının değerlendirilmesi
AU  - Uzun, Feyzahan
AU  - Fındık, Hüseyin
AU  - Beyazal Polat, Hatice
PY  - 2019
DA  - September
Y2  - 2019
DO  - 10.31362/patd.544201
JF  - Pamukkale Medical Journal
JO  - Pam Tıp Derg
PB  - Pamukkale University
WT  - DergiPark
SN  - 1308-0865
SP  - 503
EP  - 508
VL  - 12
IS  - 3
LA  - en
AB  - Purpose: To measure the retinal nerve fiber layerthickness (RNFLT) in prediabetic subjects who were diagnosed with insulinresistance and to compare with healthy controls. Materialsand methods: Eachsubject was underwent a standard ophthalmological examination including measurementof best corrected visual acuity and intraocular pressure, anterior segmentbiomicroscopy and funduscopy. Average and four quadrant (superior, temporal,inferior, nasal) RNFLT measurements were performed using spectral domainoptical coherence tomography (OCT). Plasma fasting insulin and glucose levelswere noted and homeostasis model assessment of insulin resistance index(HOMA-IR) was calculated.Results: Atotal of 37 patients with insulin resistance and 41 healthy controls wereincluded in the study. Mean age of the insulin resistant group and healthycontrols were 35.7±9.8 and 34.9±10.7 years, respectively. The average (95.03±11.38 µm vs 99.2±19.73 µm), inferior (119.11±18.27 µm vs 127.5±21.03 µm) and temporal (72.13±12.52 µm vs 79.2±15.97 µm) quadrantRNFL were significantly thinner in subjects with insulin resistance as comparedwith healthy controls (p<0.05). No significant difference was observedbetween the groups in the superior (121.01±9 µm vs 123.9±01 µm) and nasal (72.03±13.65 µm vs 74.52±10.52 µm) quadrants (p˃0.05).Conclusion: Neurodegenerationof the retina which is seen in diabetic patients may begin in the insulinresistance stage. OCT is a useful tool both in the early diagnosis andfollow-up of retinal neurodegeneration.
KW  - Diabetes mellitus
KW  - insulin resistance
KW  - optical coherence tomography
N2  - Amaç:İnsülin rezistansı tanısı ile takip edilen prediabetik bireylerde retina sinirlifi kalınlığının (RSLK) ölçümü ve sağlıklı kontrollerle karşılaştırılması.Gereç-Yöntem: Eniyi düzeltilmiş görme keskinliği, göz içi basıncı, ön segment ve fundusmuayenelerini içeren tam oftalmolojik inceleme yapıldı. RSLK spectral-domainoptik koherans tomografi (OKT) ile ölçüldü. Açlık plazma glikoz ve insülinseviyeleri not edildi ve insülin rezistans indexi (HOMA-IR) değeri hesaplandı.Bulgular:İnsülin rezistansı tespit edilen 37 birey ile 41 sağlıklı kontrol çalışmayadahil edildi. Yaş ortalaması insülin rezistansı ve kontrol grubunda sırasıyla35,7±9,8 ve 34,9±10,7 yıl idi. İnsülin rezistansı olan grupta ortalama(95,03±11,38 µm vs 99,2±19,73 µm),inferior (119,11±18,27 µm vs 127,5±21,03µm) ve temporal (72,13±12,52 µm vs79,2±15,97 µm) kadranlarda RSLK değeri kontrol grubuna göre istatistikselolarak anlamlı derecede ince tespit edildi (p<0,05).Superior (121,01±9 µm vs 123,9±01µm) ve nazal (72,03±13,65 µm vs74,52±10,52 µm) kadranlarda anlamlı bir değişiklik saptanmadı (p˃0,05). Sonuç:Prediabetik hastalarda klinik olarak herhangi bir bulgu vermese de retina sinirlifi tabakasında nörodejenerasyon insülin rezistansı evresindebaşlayabilmektedir. OKT prediabetik bireylerde erken retinal nörodejenerasyontanısı ve takibi için uygun bir araçtır.
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UR  - https://doi.org/10.31362/patd.544201
L1  - https://dergipark.org.tr/en/download/article-file/814333
ER  -