TY  - JOUR
T1  - MEZENTERİK İSKEMİ-REPERFÜZYONLA İNDÜKLENEN İNTESTİNAL DOKU HASARINA KARŞI EVODİAMİN’İN ETKİSİ: OKSİDATİF STRESİN ROLÜ The Effect of Evodiamine Against Intestinal Tissue Injury Induced By Mesenteric Ischemia-Reperfusion: Role of Oxidative Stress
AU  - Tanyeli, Ayhan
AU  - Ekinci Akdemir, Fazile Nur
AU  - Eraslan, Ersen
AU  - Güler, Mustafa Can
AU  - Topdağı, Ömer
PY  - 2019
DA  - March
DO  - 10.16919/bozoktip.454706
JF  - Bozok Tıp Dergisi
PB  - Yozgat Bozok University
WT  - DergiPark
SN  - 2146-4006
SP  - 113
EP  - 118
VL  - 9
IS  - 1
LA  - tr
AB  - ÖZETAmaç: Bu çalışma, evodiaminin mezenterik iskemi-reperfüzyonun neden olduğu intestinal dokudakioksidatif hasara karşı muhtemel yararlı etkisini göstermeyi amaçlamıştır.Materyal ve Metod: Bu amaçla çalışmamızda deney hayvanlarında mezenterik iskemi-reperfüzyonmodeli yapıldı. İskemi-reperfüzyon ve evodiamin düşük ve yüksek doz tedavi gruplarında,superior mezenterik arter 1 saat süreyle klemplendi. Daha sonra klemp açıldı ve 2 saatlik reperfüzyonbaşlatıldı. Deney sürecinin sonlandırılmasından sonra, tüm hayvanlar sakrifiye edildi veintestinal doku örnekleri toplandı.Bulgular: TOS, OSI, MDA düzeyleri ve MPO aktivitesinin sham grubuna göre mezenterik iskemireperfüzyongrubunda arttığı görüldü. ''Ayrıca mezenterik iskemi-reperfüzyon grubunda SOD aktivitesive TAS seviyesinin sham grubuna göre azaldığı tespit edildi. ''Düşük ve yüksek dozlardaevodiamin (10 ve 20 mg / kg) uygulanan gruplarda mezenterik iskemi-reperfüzyon grubuna göreTAS değeri ve SOD aktivitesi artarken, TOS, OSI değerleri, MPO aktivitesi ve MDA düzeyi azaldığıbelirlendi.Sonuç: İki farklı evodiamin dozu mezenterik iskemi-reperfüzyonun neden olduğu intestinal dokununoksidatif hasarına karşı yararlı etkiler göstermiştir.Anahtar Sözcükler: Mezenterik iskemi-reperfüzyon; Evodiamin; İntestinal doku hasarı; SıçanABSTRACTPurpose: This study aimed to show possible benefical effect of evodiamine against oxidativedamage of intestinal tissue induced by mesenteric ischemia-reperfusion.Materials and Methods: For this purpose, in our study mesenteric ischemia-reperfusion modelwas conducted in experimental animals. In low and high doses treatment of evodiamine andischemia-reperfusion groups, superior mesenteric artery was clamped for 1 h. Then, the clampwas opened and reperfusion was started for 2 h. After the termination of the experimentalprosses, all animals were sacrificed and intestinal tissue samples were collected.Results: It was seen that TOS, OSI, MDA levels and MPO activity increased in mesenteric ischemiareperfusiongroup compared to sham group. Moreover, SOD activity and TAS level reduced inmesenteric ischemia-reperfusion group compared to sham group. When compared to mesentericischemia-reperfusion group, TAS value and SOD activity increased while TOS, OSI values, MPOactivity and MDA level decreased in groups treated with low and high doses of evodiamine (10and 20 mg/kg).Conclusion: Two different doses of evodiamine revealed benefical effects against oxidativedamage of intestinal tissue induced by mesenteric ischemia-reperfusion.Keywords: Mesenteric ischemia-reperfusion; Evodiamine; Intestinal tissue damage; Rat
KW  - MEZENTERİK İSKEMİ-REPERFÜZYONLA İNDÜKLENEN İNTESTİNAL DOKU HASARINA KARŞI EVODİAMİN’İN ETKİSİ: OKSİDATİF STRESİN ROLÜ The Effect of Evodiamine Against Intestinal Tissue Injury Induced By Mesenteric Ischemia-Reperfusion: Role of Oxidative Stress
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UR  - https://doi.org/10.16919/bozoktip.454706
L1  - https://dergipark.org.tr/en/download/article-file/679993
ER  -