TY - JOUR TT - Normal Platelet Parameters in Childhood Period from Newborns to Adolescents AU - Akarsu, Saadet AU - Şengül, İsmail AU - Tosun, Mehtap Durukan AU - Benzer, Derya AU - Aygün, A. Denizmen PY - 2012 DA - December JF - Meandros Medical And Dental Journal JO - Meandros Med. Den. j. PB - Aydin Adnan Menderes University WT - DergiPark SN - 2149-9063 SP - 1 EP - 5 VL - 13 IS - 3 N2 - PURPOSE:There are few studies on normal values of platelet parameters as mean platelet volume (MPV), thrombocytocrite (PCT) and platelet distribution width (PDW) in children. The aim of this study is to determine the normal values of these platelet parameters in healthy Eastern Turkish children. MATERIALS and METHODS:This study is realized in Healthy Child Clinic of Fırat University Medical Facullty on a total number of 1005 children, between 0 to 14 years old, who have normal growth and developmental features. Their blood samples were collected by venipuncture of the arm. Platelet values determined in an automatic counter (Advia 120, Japan) were used in the statistical analysis to calculate the mean and standart deviation. To determine the differentiations between age groups one way Anova was used and p<0.05 was accepted as significant. RESULTS:Platelet count and PCT values are decreased in neonatal period. These values are increased slightly in infantile period and are decreased again in adolescent period. For MPV extremely low values are in neonatal period, and after these values increase from infantile to adolescent period. However PDW values are apparently increased in neonatal period and than go along in a constant interval. CONCLUSIONS:The values of platelet indices obtained in this study were similar to different reports and may be used as reference values in pediatric patients with clinical problems related to these cells. CR - Wiwanitkit V. Plateletcrit, mean platelet volume, Ýlknur Varol, Yaþar Þen. Deðiþik hastalýk gruplarýnda trombosit hacim deðiþkenleri. Türk Pediatri Arþivi ; 41:208-13. correlation with parallel red blood cell parameters. Clin Appl Thromb Hemost 2004; 10:175-8. CR - Park Y, Schoene N, Harris W. Mean platelet volume as Osselaer JC, Jamart J, Scheiff JM. Platelet distribution an indicator of platelet activation: methodological issues. Platelets 2002; 13:301-6. width for differential diagnosis of thrombocytosis. Clin Chem 1997; 43:1072-6. CR - Quintó L, Aponte JJ, Sacarlal J, et al. Haematological Robert A, Boneu B, Corberand J, Goudable JP, Regnier and biochemical indices in young African children: in search of reference intervals. Trop Med Int Health ; 11:1741-8. hematology. Practical value (author's transl). Nouv Presse Med 1978; 7:739-42. CR - Taylor MR, Holland CV, Spencer R, Jackson JF, Israels SJ, Rand ML, Michelson AD. Neonatal platelet function. Semin Thromb Hemost 2003; 29:363-72. CR - Wasiluk A1, Osada J, D¹browska M, Szczepañski M, O'Connor GI, O'Donnell JR. Haematological reference ranges for schoolchildren. Clin Lab Haem 1997; 19:1 CR - Jasinska E. Does prematurity affect platelet indices? Advances in Medical Sciences 2009; 54:253-5. CR - Adetifa IM, Hill PC, Jeffries DJ, et al. Haematological values from a Gambian cohort--possible reference range for a West African population. Int J Lab Hematol ; 31:615-22. Hotchen M, Samama M. Discriminant study of platelet volume indices in the etiological diagnosis of thrombocytopenia. Acta Haematol 1984;71:25-31. CR - Becerre-Flores MC, Farfán-Canto JM, Nieva-García B, Desideri G, De Simone M, Iughetti L, et al. Early activation of vascular endothelial cells and platelets in obese children. J Clin Endocrinol Metab 2005; :3145-52. YAZIÞMA ADRESÝ CR - Prof. Dr. Saadet AKARSU Fýrat Üniversitesi Týp Fakültesi, Pediatrik Hematoloji BD, ELAZIÐ, TÜRKÝYE E-Posta: aksaadet@yahoo.com Geliþ Tarihi Kabul Tarihi : 14.11.2012 UR - https://dergipark.org.tr/en/pub/meandrosmdj/issue//545591 L1 - https://dergipark.org.tr/en/download/article-file/681386 ER -