TY  - JOUR
TT  - Evaluation of Children with Suspected Beta Lactam Allergy:A Retrospective Study
AU  - Sözmen, Şule Çağlayan
AU  - Köse, Seda
AU  - Tezcan, Dilek
AU  - Işık, Sakine
AU  - Ayyıldız, Zeynep Arıkan
AU  - Asilsoy, Suna
AU  - Uzuner, Nevin
AU  - Anal, Özden
AU  - Karaman, Özkan
PY  - 2017
DA  - April
JF  - Türkiye Çocuk Hastalıkları Dergisi
JO  - Türkiye Çocuk Hast Derg
PB  - T.C. Sağlık Bakanlığı Ankara Şehir Hastanesi
WT  - DergiPark
SN  - 1307-4490
SP  - 40
EP  - 45
VL  - 11
IS  - 1
KW  - Çocuk
KW  - Beta laktam alerjisi
KW  - İlaç
N2  - Objective: Hypersensitivity reactions to beta-lactams are often reported in children. Although many of these children are considered to be allergic, a careful evaluation only confirms a low percentage. The aim of this study was to evaluate the clinical data and diagnostic methods used in children with a clinical history of hypersensitivity reactions to betalactams.Material and Methods: The medical records of patients presenting with suspected beta-lactam allergy were evaluated retrospectively between June 2013 to December 2015 at the Dokuz Eylul University’s Department of Pediatric Allergy and Immunology.results: In total, data of 33 patients were obtained from medical records. Only 5 (13.8%) of the patients had an allergy. Skin prick test, intradermal test and oral provocation test (OPT) were administered to 15 (45.4%) patients and 3 of the patients were diagnosed as having hypersensitivity to culprit drugs (1 amoxicillin, 1 cefuroxime and 1 both cefuroxime and ampicillin). A total of 18 patients with non-immediate cutaneous reactions without systemic symptoms were administered penicilloyl G- and V-specific immunoglobulin E (IgE) and OPT and 2 patients were diagnosed as having isolated clavulanic acid allergy.conclusion: Beta-lactam allergies could be overdiagnosed and a careful evaluation should be performed for accurate diagnosis. For children with non-immediate cutaneous reactions, OPTs are safe and effective
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UR  - https://dergipark.org.tr/en/pub/tchd/issue//546839
L1  - https://dergipark.org.tr/en/download/article-file/683559
ER  -