@article{article_548460, title={IN VITRO EVALUATION OF ELECTROSPUN POLYSACCHARIDE BASED NANOFIBROUS MATS AS SURGICAL ADHESION BARRIERS}, journal={Textile and Apparel}, volume={30}, pages={99–107}, year={2020}, DOI={10.32710/tekstilvekonfeksiyon.548460}, author={Şafak, Şerife and Vatan, Özgür and Çinkılıç, Nilüfer and Karaca, Esra}, keywords={nanofiber,adhesion barrier,polysaccharide polymers, in vitro}, abstract={<p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:200%;"> <font style="background-color:rgb(255,255,255);"> <a> <span style="line-height:200%;" lang="en-us" xml:lang="en-us">Postoperative adhesions are one of the most important
problems that the patients and surgeons face. In this study, nanofibrous mats
as a novel surgical adhesion barrier were produced from polysaccharide-based
polymers, hyaluronic acid, carboxymethyl cellulose and sodium alginate, via
electrospinning. The produced nanofibrous mats were crosslinked with </span> </a> <span> <span style="line-height:200%;" lang="en-us" xml:lang="en-us">1-ethyl-3-(3-dimethylaminopropyl)
carbodiimide hydrochloride </span> </span> <span> <span style="line-height:200%;" lang="en-us" xml:lang="en-us"> and
N-hydroxysulfosuccinimide. Furthermore, the morphology, and the <i>in vitro </i> degradation, cytotoxicity and
cell adherence potential of the nanofibrous mats aimed to be used as adhesion
barriers were evaluated and compared with a commercial adhesion barrier. </span> </span> <span> <span style="line-height:200%;" lang="en-us" xml:lang="en-us">After the crosslinking process,
the nanofibrous structure was maintained, and the diameters of resulting
nanofibers were below 300 nm. </span> </span> <span> <span style="line-height:200%;" lang="en-us" xml:lang="en-us">Results of the <i>in vitro </i> experiment showed that the
nanofibrous mats have maintained their physical structures during the critical
period for adhesion formation, and had non-adherent cell feature and non-cytotoxic
nature required for an ideal adhesion barrier. </span> </span> </font> </p>}, number={2}, publisher={Ege University}