@article{article_548974, title={Epilepsy Clinical Characteristics of Patients with Neurofi bromatosis Type 1 and Epilepsy}, journal={Türkiye Çocuk Hastalıkları Dergisi}, volume={8}, pages={137–140}, year={2014}, url={https://izlik.org/JA76XU25HU}, author={Bektaş, Ömer and Teber, Serap and Deda, Gülhis}, keywords={Child, Epilepsy, Seizures, Neurofi bromatosis type 1}, abstract={Objective: Epilepsy occurs in approximately 4-7% of individuals with Neurofi bromatosis type 1 (NF1). This is higher than the 1-2% value reported for the general population. The aim of the study was to describe the clinical characteristics and outcomes of individuals with NF1 and epilepsy.Material and Methods: This study evaluated 35 patients who were followed up for NF1 at our tertiary care center between January 2000 and February 2010. Every patient underwent electroencephalographic examination and neuroimaging investigations.Results: A history of at least one unprovoked seizure was present in 34.2% of NF1 patients and 17.1% had documented epilepsy. Focal seizures were the most common type, occurring in 57% of individuals, although generalized seizures were also noted. Epilepsy presented with brain lesions such as cerebral hamartoma in two patients and unidentifi ed bright objects in three patients. Seizures were controlled with a single antiepileptic drug in three (50%) and multiple antiepileptic drugs in three (50%) patients.Conclusion: Our observations and our re-evaluation of the literature indicate that patients with neurofi bromatosis 1 have an increased risk of epilepsy related to intracranial lesions and seizures can represent the fi rst symptom of a tumor or cortical lesions. We conclude that radiological follow-up should be considered in NF1 patients with seizures}, number={3}