TY  - JOUR
TT  - Epilepsy Clinical Characteristics of Patients with Neurofi bromatosis Type 1 and Epilepsy
AU  - Bektaş, Ömer
AU  - Teber, Serap
AU  - Deda, Gülhis
PY  - 2014
DA  - June
JF  - Türkiye Çocuk Hastalıkları Dergisi
JO  - Türkiye Çocuk Hast Derg
PB  - T.C. Sağlık Bakanlığı Ankara Şehir Hastanesi
WT  - DergiPark
SN  - 1307-4490
SP  - 137
EP  - 140
VL  - 8
IS  - 3
KW  - Çocuk
KW  - Epilepsi
KW  - Nöbetler
KW  - Nörofi bromatozis Tip 1
N2  - Objective: Epilepsy occurs in approximately 4-7% of individuals with Neurofi bromatosis type 1 (NF1). This is higher than the 1-2% value reported for the general population. The aim of the study was to describe the clinical characteristics and outcomes of individuals with NF1 and epilepsy.Material and Methods: This study evaluated 35 patients who were followed up for NF1 at our tertiary care center between January 2000 and February 2010. Every patient underwent electroencephalographic examination and neuroimaging investigations.Results: A history of at least one unprovoked seizure was present in 34.2% of NF1 patients and 17.1% had documented epilepsy. Focal seizures were the most common type, occurring in 57% of individuals, although generalized seizures were also noted. Epilepsy presented with brain lesions such as cerebral hamartoma in two patients and unidentifi ed bright objects in three patients. Seizures were controlled with a single antiepileptic drug in three (50%) and multiple antiepileptic drugs in three (50%) patients.Conclusion: Our observations and our re-evaluation of the literature indicate that patients with neurofi bromatosis 1 have an increased risk of epilepsy related to intracranial lesions and seizures can represent the fi rst symptom of a tumor or cortical lesions. We conclude that radiological follow-up should be considered in NF1 patients with seizures
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CR  - Rodriguez FJ, Perry A, Gutmann DH, O’Neill BP, Leonard J, Bryant S, et al. Gliomas in neurofi bromatosis type 1: A clinicopathologic study of 100 patients. J Neuropathol Exp Neurol 2008;67:240-9.
CR  - Hsieh HY, Fung HC, Wang CJ, Chin SC, Wu T. Epileptic seizures in neurofi bromatosis type 1 are related to intracranial tumors but not to neurofi bromatosis bright objects. Seizure 2011;20:606-11.
UR  - https://dergipark.org.tr/en/pub/tchd/article/548974
L1  - https://dergipark.org.tr/en/download/article-file/687613
ER  -