@article{article_550012, title={DOES MITRAL VALVE PROLAPSE HAVE RELATION WITH AUTOIMMUNITY OR NOT? EVALUATION OF PEDIATRIC CASES}, journal={Türkiye Çocuk Hastalıkları Dergisi}, volume={5}, pages={156–161}, year={2011}, author={Örün, Utku Arman and Keskin, Mahmut and Doksöz, Önder and Karademir, Selmin and Doğan, Vehbi and Ceylan, Özben and Özgür, Senem and Yılmaz, Osman and Öcal, Burhan and Şenocak, Filiz and et al.}, keywords={Mitral valve prolapse, autoimmunity, IgA deficiency, childhood}, abstract={Aim: Mitral valve prolapse (MVP) is a common cardiac valvular disease. Besides genetic and neuroendocrine factors, autoimmunity is thought to play a role in its pathogenesis. In this study, we aimed to evaluate the role of autoimmunity in development of MVP through the screening of certain markers related with autoimmunity. Materials and methods: Between May 2009 and December 2009; a total of 38 patients followed with the diagnosis of MVP in the Pediatric Cardiology Department of Dr. Sami Ulus Maternity and Children’s Education and Research Hospital and a control group consisting of 38 healthy children were included in the study. Acute phase reactants, biochemical tests, levels of serum immunoglobulin, complement levels, antinuclear antibodies, antithyroid antibodies, rheumatoid factor, anticardiolipin, and antiphospholipid antibodies were all determined. Electrocardiography, telecardiography, and echocardiography were also performed in all cases. Results: In the comparison of two groups, no statistically significant difference was shown concerning autoimmunity markers (p>0.05). Four children in the patient group (3 with partial and one with selective Ig A deficiency) and 2 children in the control group (2 with partial Ig A deficiency) had low Ig A levels, whereas the difference between two groups were not statistically significant (p>0.05). Conclusion: In our study, no significant correlation was found between MVP and autoimmune markers. However, we observed that Ig A deficiency is more frequent in the patient group than in the control group. In spite of the statistically non-significant association between MVP and autoimmunity markers, we conclude that children with MVP having Ig A deficiency should be followed up for the development of autoimmune disoredrs in their future life}, number={3}, publisher={T.C. Sağlık Bakanlığı Ankara Şehir Hastanesi}