TY  - JOUR
TT  - Feeding Behaviour: Pharmacological Target Molecules
AU  - Gültekin, Hülya
AU  - Şahin, Serkan
AU  - Budak, Nurten
PY  - 2004
DA  - March
JF  - Sağlık Bilimleri Dergisi
JO  - JHS
PB  - Erciyes University
WT  - DergiPark
SN  - 1018-3655
SP  - 77
EP  - 87
VL  - 13
IS  - 1
KW  - İştah
KW  - ilaç
KW  - şişmanlık
KW  - zayıflık
KW  - leptin
KW  - nöropeptid Y
KW  - sitokin
N2  - Obesity and leanness are the results of the imbalance between energy intake and expenditure. Obesity has important roles in the etiology of tip II diabetes mellitus and cardiovascular diseases. On the other hand, anorexia-cachexia is the most frequent cause of cancer related deaths. So, it is important to know how energy balance is regulated so that these preventing or treating diseases can be prevented or treated. Energy homeostasis is maintained by complex and dynamic processes interacting with each other. Hypothalamus plays a key role in coordination and integration of stimuli from peripheral tissuses such as gastrointestinal system and fat tissue and from several regions of central nervous system. It also has important roles in appropriate adaptive response. Many neuromediator and hormons such as leptin, neuropeptide Y, orexins, derivates of proopiomelanocortin, agouti-related protein, cocaine and amphetamine-regulated transcript, cholecystokinin, serotonin, noradrenalin, insulin, glucagon and glucagon like peptide, corticotrophin releasing factor and corticosteroids, ghrelin, galanin and galanin like peptide, bombesin and its homolouge as gastrin releasing peptide in human, opioids, cannabinoids, neurotensin, nitric oxide and several cytokines such as TNF-α, IL1, IL6, ciliary neurotrophic factor mediate stimuli terminating in hypothalamus. So they contribute to feeding behaviour. It is also important to know the other actions of these molecules apart from their roles in feeding when predicting the side effect profiles of new drugs targeting these molecules
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UR  - https://dergipark.org.tr/en/pub/eujhs/issue//551656
L1  - https://dergipark.org.tr/en/download/article-file/691839
ER  -