TY - JOUR TT - An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes AU - Çelik Kazıcı, Hilal PY - 2020 DA - March Y2 - 2019 DO - 10.17798/bitlisfen.558198 JF - Bitlis Eren Üniversitesi Fen Bilimleri Dergisi PB - Bitlis Eren University WT - DergiPark SN - 2147-3129 SP - 357 EP - 365 VL - 9 IS - 1 LA - en KW - Beta-bloker KW - İndirgenmiş grafen oksit KW - Yüzey baskılı elektrot N2 - Buçalışmada, propranololün elektrokimyasal davranışı, indirgenmiş grafen oksit(rGO) ile modifiye edilmiş yüzey baskılı karbon elektrotlar (SPCE) ileincelenmiştir. Oksidasyon işlemi, döngüsel voltametri (CV) ve diferansiyel pulsvoltametri (DPV) teknikleri kullanılarak gerçekleştirilmiştir. Sonuçlar,rGO'nun oksidasyon pik akımını artırarak bu ilaçları uygun potansiyellerdeoksitlediğini göstermiştir. Modifiye edilmiş SPCE, beta-blokerlerin, fosfattampon çözeltisinde (PBS) alışılmadık derecede pozitif bir potansiyeldeoksidasyonuna doğru mükemmel katalitik aktivite sergilemiştir. Propranololüntespiti için önerilen sensörün doğrusal konsantrasyon aralığı ve tespit limiti,sırasıyla, 50 µM ve 2.61 µM olarak elde edilmiştir. CR - 1. Moscou K., Snıpe K. 2013. Pharmacology for Pharmacy Technicians, Elsevier, 354–357, Missouri. CR - 2. Vázquez P., Martínez Galera M., Serrano Guirado A., 2010. Determination of five beta-blockers in wastewaters by coupled-column liquid chromatography and fluorescence detection, Analytica Chimica Acta, 666: 38-44. CR - 3. Sendon J.L., Swedberg K., McMurray J., Tamargo J., Maggioni A.P., Dargie H., 2004. Expert consensus document on beta-adrenergic receptor blockers, Europen Society of Cardiology, 25: 1341-1362. CR - 4. Frishman W.H. 2008. Beta-adrenergic blockers: a 50-year historical perspective, American Journal of Therapeutics, 15:565–76. CR - 5. Santoro M.I.R.M., Cho H.S., Kedor-Hachman E.R.M. 1996. Simple template-free solution route for the synthesis of Cu(OH)2 and CuO nanostructures and application for electrochemical determination three ß-blockers, Analytical Letters, 29:775. CR - 6. Siren H., Saarinen M., Hainari S., Riekkola M.L., 1993. Screening of beta-blockers in human serum by ion-pair chromatography and their identification as methyl or acetyl derivatives by gas chromatography-mass spectrometry, Journal of Chromatography A, 632:215. CR - 7. Clohs L., McErlane K.M., 2003. Comparison between capillary electrophoresis and high-performance liquid chromatography for the stereoselective analysis of carvedilol in serum, Journal of Pharmaceutical and Biomedical Analysis, 31:407. CR - 8. Modamio P., Lastra C.F., Marino E.L., 1998. Error structure for the HPLC analysis for atenolol, metoprolol and propranolol: a useful weighting method in parameter estimation. Journal of Pharmaceutical and Biomedical Analysis, 17:507. CR - 9. Nasrin S., Mohammad H., Lotfali S., Robab M., Abolghasem J., 2011. Electrochemical behavior of atenolol, carvedilol and propranolol on copper-oxide nanoparticles, Electrochimica Acta, 58:336–347. CR - 10. Nassef H.M., Cıvıt L., Fragoso A. And Sullıvıan C.K., 2008. Amperometric sensing of ascorbic acid using a disposible screen-printed electrode modified with electrografted o-aminophenol film. Analyst, 133:1736-1741. CR - 11. Mccreey R. L. 2008. Advanced Carbon Electrode Materials for Molecular Electrochemistry, Chem Rev, 108:2646-2687. CR - 12. Serafın V., Agul L., Yanez-Sedeno P., Pıngarron J.M. 2011. A novel hybrid platform for the preparation of disposable enzyme biosensors based on poly(3,4-ethylenedioxythiophene) electrodeposition in an ionic liquid medium onto gold nanoparticles-modified screen-printed electrodes. Journal of Electroanal Chem, 656:152-158. CR - 13. Olson M.P., Lacourse W.R., 2004. Voltammetry. In: Ewing's Analytical Instrumentation Handbook, Ed.: Cazes, J., 3rd Ed. Boca Raton FL: CRC Press, 529–544. CR - 14. Greef, R.G., Peat R., Peter, L.M., Pletcher, D., Robınson, J., 1990. Instrumental Methods in Electro Chemistry. London, Ellis Horwood series in Physical Chemistry. CR - 15. Kazici, H.Ç., 2018. The Ultra-sensitive method development using Nafion and multi-walled carbon nanotube coated glassy carbon electrode for atenolol determination. Pamukkale University Journal of Engineering Sciences, 24:1287-1292. UR - https://doi.org/10.17798/bitlisfen.558198 L1 - https://dergipark.org.tr/en/download/article-file/998842 ER -