@article{article_560531, title={Efficacy and safety of single high-dose versus double high-dose intracoronary bolus tirofiban in patients with ST-segment elevation myocardial infarction}, journal={The European Research Journal}, volume={7}, pages={12–21}, year={2021}, DOI={10.18621/eurj.560531}, author={Kaplan, Mehmet and Kurt, İbrahim Halil and Quısı, Alaa and Alıcı, Gökhan and Demir, Şerafettin and Yavuz, Fethi and Dönmez, Yurdaer}, keywords={high-dose, glycoprotein IIb/IIIa receptor inhibitor, tirofiban, ST-segment elevation myocardial infarction, efficacy, safety}, abstract={<p class="MsoNormal" style="text-align:justify;line-height:200%;"> <span style="font-size:14px;"> <b>Objectives: </b> We evaluated the efficacy and safety of single high-dose versus double high-dose intracoronary bolus tirofiban in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). </span> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <span style="font-size:14px;"> <b>Methods: </b>A total of 80 patients, who were admitted to our clinic and underwent primary PCI, were included in this observational cohort study. The patients were divided into the single high-dose group (n = 40) and the double high-dose group (n = 40) according to the intracoronary bolus tirofiban regime. The primary endpoint was assumed as the incidence of major adverse cardiac event (s) (MACE) defined as all-cause mortality and repeat coronary revascularization (target vessel revascularization [TVR]) at 30 days. MACE and bleeding events were evaluated at 7 and 30 days. </span> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <span style="font-size:14px;"> <b>Results: </b>The primary endpoint was not significantly different between the single and the double high-dose groups (40.0% vs. 17.5%, p = 0.994). However, a significantly lower 30-day TVR rate was observed in the double high-dose group (27.5% vs. 7.5%, p = 0.019). No significant difference was observed in terms of 30-day all-cause mortality between the two groups (12.5% vs. 10.0%, p = 0.712). Major bleeding events were not observed in any group. Multivariate logistic regression analysis demonstrated that CRUSADE score (Hazard ratio [HR]: 5.721; 95% CI: 2.036 to 16.073, p = 0.001) and platelet count (HR: 1.009; 95% CI: 1.000 to 1.018, p = 0.048) were the independent predictors of bleeding at 7 days. </span> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <span style="font-size:14px;"> <b>Conclusions: </b> Double high-dose intracoronary bolus tirofiban in STEMI patients undergoing primary PCI was associated with significantly lower 30-day TVR rates without an increase in bleeding events. However, it did not significantly affect MACE and all-cause mortality rates.  </span> <br /> </p> <p> </p>}, number={1}, publisher={Prusa Medical Publishing}