@article{article_569286, title={Importance of human umbilical vein endothelial cells in experimental cardiovascular studies}, journal={Turkish Journal of Clinics and Laboratory}, volume={10}, pages={259–261}, year={2019}, DOI={10.18663/tjcl.569286}, author={Akbay, Esin}, keywords={human umbilical vein endothelial cells,cardiovascular diseases,in vitro,models}, abstract={<p class="western" align="justify" style="margin-bottom:.35cm;line-height:200%;"> <font face="Times New Roman, serif"> <font style="font-size:12pt;"> <span lang="en-us" xml:lang="en-us">Nowadays,
cardiovascular system disorders caused by narrowing or obstruction of
the vascular system lead to the most important diseases that have a
negative effect on the quality of life and have fatal consequences.
It is known that many diseases are accompanied by cardiovascular
system disorders. For these reasons, studies on the existence of
different pathways activated in cardiovascular pathology and the
investigation of these pathways have come intoquestion, and </span> </font> </font> <font face="Times New Roman, serif"> <font style="font-size:12pt;"> <span lang="en-us" xml:lang="en-us"> <i>in
vitro </i> </span> </font> </font> <font face="Times New Roman, serif"> <font style="font-size:12pt;"> <span lang="en-us" xml:lang="en-us">
methods have been needed to be developed. </span> </font> </font> <font face="Times New Roman, serif"> <font style="font-size:12pt;"> <span lang="en-us" xml:lang="en-us"> <i>in
vitro </i> </span> </font> </font> <font face="Times New Roman, serif"> <font style="font-size:12pt;"> <span lang="en-us" xml:lang="en-us">
cell culture models are the preferred models to enable understanding
the mechanisms that regulate the process of angiogenesis. Human
umbilical vein endothelial cells (HUVEC) are one of the most common </span> </font> </font> <font face="Times New Roman, serif"> <font style="font-size:12pt;"> <span lang="en-us" xml:lang="en-us"> <i>in
vitro </i> </span> </font> </font> <font face="Times New Roman, serif"> <font style="font-size:12pt;"> <span lang="en-us" xml:lang="en-us">cell
models used in vascular studies within the scope of cardiovascular
pathology. This review focuses on the use of HUVECs as an </span> </font> </font> <font face="Times New Roman, serif"> <font style="font-size:12pt;"> <span lang="en-us" xml:lang="en-us"> <i>in
vitro </i> </span> </font> </font> <font face="Times New Roman, serif"> <font style="font-size:12pt;"> <span lang="en-us" xml:lang="en-us">
model to evaluate different therapeutic approaches. </span> </font> </font> </p>}, number={2}, publisher={DNT Ortadoğu Yayıncılık A.Ş.}