TY  - JOUR
T1  - Tuberculosis and vitamin D
TT  - Tüberküloz ve D vitamini
AU  - Akşit İlki, Arzu
PY  - 2014
DA  - May
JF  - Marmara Medical Journal
JO  - Marmara Med J
PB  - Marmara University
WT  - DergiPark
SN  - 1019-1941
SP  - 85
EP  - 88
VL  - 27
IS  - 2
LA  - en
AB  - Tuberculosis (TB) is still highly prevalent world-wide accountingfor over one million deaths annually. Especially the multi drugresistant Mycobacterium tuberculosis necessitates the developmentof new agents to enhance the response to antimicrobial therapy foractive TB. In the pre-antibiotic era, vitamin D was used to treatTB. However, after the development of antituberculosis agents, itlost its importance. Recently, its active metabolite,1,25-dihydoxyvitamin D, was shown to enhance the immuneresponse to mycobacteria. Vitamin D does not have a direct killingeffect but 1,25-dihydoxyvitamin D, is a modulater of the immunesystem. The synthesis of 1,25-dihydroxyvitamin D promotes theproduction of endogen defensin and cathelicidin. These productshave a direct lethal effect on bacteria and intracellularmicroorganisms like M.tuberculosis.In this review, the role of vitamin D in host resistance toM.tuberculosis infection and its effect for supplementation therapyis discussed.
KW  - Tuberculosis
KW  - Vitamin D
KW  - 1
KW  - 25-dihydoxyvitamin D
KW  - Immune response
KW  - Defensin
KW  - Cathelicidin
N2  - Tüberküloz, hala tüm dünyada yılda bir milyondan fazla kişininölümüne yol açan en yaygın hastalıklardan biridir. Özellikle çokluilaca dirençli Mycobacterium tuberculosis enfeksiyonlarındaantimikrobiyal tedavi cevabını arttırmak için yeni ajanlarıngelişimine ihtiyaç duyulmaktadır. Antibiyotik öncesi dönemdetüberküloz tedavisinde kullanılan D vitamini, antitüberkülozilaçların gelişimiyle önemini yitirmiştir. Son zamanlarda D vitaminiaktif metaboliti, 1,25-dihydroxyvitamin D’nin mikobakterilerdebağışık yanıtı arttırdığı bilinmektedir. D vitamininin direktöldürücü etkisi yoktur, ancak 1,25-dihydoxyvitamin D, bağışıkyanıt üzerinde modülator görevi yapar. 1,25-dihydroxyvitamin Dsentezi endojen defensin ve katelisidin sentezini arttırır. Buürünlerin bakterilere ve M.tuberculosis gibi hücre içi yerleşimlimikroorganizmalara direkt ölümcül etkileri vardır.Bu derlemede, D vitamininin, M.tuberculosis enfeksiyonundakonak direncindeki rolü ve destek tedavisi ile ilgili etkileritartışılmıştır.
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UR  - https://dergipark.org.tr/en/pub/marumj/issue//570960
L1  - https://dergipark.org.tr/en/download/article-file/725131
ER  -