@article{article_576695, title={Anti-Proliferative Effect of Melamine on Human Colon Adenocarcinoma Cells}, journal={Kocatepe Veterinary Journal}, volume={12}, pages={264–267}, year={2019}, DOI={10.30607/kvj.576695}, author={Tutun, Hidayet}, keywords={Anti-proliferative,Caco-2,Melamine,MTT}, abstract={<p class="MsoNormal" style="text-align:justify;"> <span lang="en-us" style="font-size:11pt;font-family:Garamond, serif;" xml:lang="en-us">Melamine is an organic chemical used primarily as a
plastics stabilizer and fire retardant. Also, it was used to fraudulently
elevate the protein content of animal feed and dairy products, which led to
infant kidney diseases and pet deaths. In this study, melamine was studied for
its effects on growth in the human colon adenocarcinoma cells (Caco-2).
Different concentrations of medium-dissolved melamine were incubated for 24 h
with Caco-2 cells and tested for its anti-proliferative potential using MTT
assay. Half-maximal inhibitory concentration (IC <sub>50 </sub>) of melamine was
calculated from dose-response curve and found to be 14636 µg/L in the cells.
The results demonstrated that the dose dependent melamine decreased cell
proliferation and direct anti-proliferative effect in Caco-2 cells.  </span> </p> <p> </p> <p> </p>}, number={3}, publisher={Afyon Kocatepe University}