TY  - JOUR
T1  - Vitamin D in Patients With Duchenne Muscular Dystrophy
TT  - Duchenne Muskuler Distrofili Hastalarda Vitamin D Düzeyi
AU  - Sertpoyraz, Filiz Meryem
AU  - Tiftikcioglu, Bedile İrem
AU  - Baydan, Figen
AU  - Tunçay, Bakiye
AU  - Halıcıoğlu Baltalı, Oya
PY  - 2019
DA  - June
DO  - 10.17098/amj.582015
JF  - Ankara Medical Journal
JO  - Ankara Med J
PB  - Ankara Yildirim Beyazit University
WT  - DergiPark
SN  - 2148-4570
SP  - 307
EP  - 315
VL  - 19
IS  - 2
LA  - en
AB  - Objectives: Duchenne MuscularDystrophy (DMD) is one of the neuromuscular junction dystrophies, characterizedby deficiency of dystrophin and inherited as an X-linked recessive trait. Ithas a progressive nature, and results in loss of ambulation and death. Poorbone-marrow health is an important issue in terms of morbidity in DMD. VitaminD is an important pre-prohormone related to bone health. Although steroids usedin treatment of DMD are effective on progression of the disease they haveadverse effects on bone heatlh and 25(OH)-vitamin D (vitamin D) levels. Weaimed in the present study to investigate levels of vitamin D and itsrelationship with steroid use and ambulation in the patients with DMD.Materialand Metods: The present study is a case-control studyincluding 96 male patients aged between 2 to 18 years with diagnosis of DMD and48 healthy volunteers with matching gender and age distribution.Results:Deficiency or insufficiency of vitamin D level was found in 95.83% of thepatients with DMD. The patients with DMD were compared to the healthyvolunteers and significantly lower level of vitamin D was found in the group ofpatients (p = 0.003). No significant difference was found in levels of vitaminD between the patients with DMD who were using steroids and those not usingsteroids and between the patient who were ambulated or not ambulated (p = 0.741and p=0.785).Conclusion:Majority of the patients with DMD had deficient or insufficient level ofvitamin D. Thus, in the terms of protecting bone health it is important to assesslevel of vitamin D regularly from the early stages of the disease and duringthe routine controls, to implement additional treatments in the case ofdeficiency or insufficiency.
KW  - Duchenne Muscular Dystrophy
KW  - Vitamin D
KW  - Steroid
N2  - Amaç: Duchenne Musküler Distrofi (DMD), kavşaktipi distrofilerden olup X’e bağlı resesif geçen, distrofin eksikliğikarakterize kas hastalığıdır. İlerleyicidir, ambulasyon kaybı ve erken dönemdeölümlere yol açar. Zayıf kemik sağlığı DMD’de morbidite açısından önemli birsorundur. Vitamin D, kemik sağlığı açısından önemli bir preprohormondur. DMDtedavisinde kullanılan steroidlerin hastalığın progresyonu üzerinde etkintedavisi olmasına rağmen kemik sağlığı ve vitamin D üzerinde olumsuz etkileribulunmaktadır. DMD’li hastalarda serum 25(OH)vitamin D (vitamin D) düzeylerini,vitamin D’nin steroid kullanımı ve ambulasyonla ilişkisini değerlendirmeyiamaçlandık.Materyal-Metot: Vakakontrol olan çalışmaya doksan altı kesin DMD tanısı almış, 2-18 yaş, erkekhasta ve kırk sekiz benzer yaş ortalaması ve cinsiyette sağlıklı gönüllüleralındı.Bulgular:DMD’li hastalarda %95,83 oranında vitamin D düzeylerinde eksiklik – yetersizliksaptandı. DMD ‘li hastalar ile sağlıklı gönüllüler karşılaştırıldı, vitamin Ddüzeylerinde hasta grubunda anlamlı düşüklük saptandı (p=0.003). DMD’li steroidalan ve almayanlar ile ambulasyonu olan ve olmayan hastalar arasında vitamin Ddüzeyleri açısından fark saptanmadı (p=0.741 ve p=0.785).Sonuç:DMD’li hastalarda, yüksek oranda vitamin D düzeylerinde eksiklik-yetersizlikmevcuttu. Bu nedenle D vitamin düzeylerinin erken dönemden itibaren ve rutinkontrollerde düzenli değerlendirilmesi ve eksiklik-yetersizliğinde ilavetedavilerinin yapılması kemik sağlığını korumak açısındanoldukça önemlidir.
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UR  - https://doi.org/10.17098/amj.582015
L1  - https://dergipark.org.tr/en/download/article-file/744865
ER  -