TY  - JOUR
T1  - Synthesis of New p-Alkylaminophenol Compounds and  Investigation of Their Antimicrobial and Antioxidant Activity
TT  - Yeni p-alkilaminofenol Bileşiklerinin Sentezi ve  Antimikrobiyal ve Antioksidan Aktivitelerinin Araştırılması
AU  - Ulaş, Yeliz
AU  - Özkan, Ahmet İsmail
AU  - Tolan, Veysel
PY  - 2019
DA  - August
DO  - 10.31590/ejosat.582483
JF  - Avrupa Bilim ve Teknoloji Dergisi
JO  - EJOSAT
PB  - Osman SAĞDIÇ
WT  - DergiPark
SN  - 2148-2683
SP  - 701
EP  - 706
IS  - 16
LA  - en
AB  - Alkylaminophenols are synthetic derivatives wellknown for their anticancer activity. In this work, we report the antimicrobialand antioxidant activity of such compounds. A series (4,5,6) ofalkylaminophenol compounds were prepared with very high yields by Petasisreaction. Synthesized compounds were characterized by 1H-NMR and 13C-NMR.The obtained compounds were tested against Gram-positive and Gram-negativebacteria. The compound 4 showed antimicrobial activity at a concentration of 10mg/mL, while the 6 compound showed activity on S. aureus. Phenolic compoundshave attracted attention due to their proximal and antioxidant activities.Since alkylaminophenols have phenolic structure, their antioxidant activity hasbeen investigated. Thus, drug-active substances with high antioxidant capacityagainst diabetes, heart disease, and cancer were synthesized.
KW  - Alkylaminophenol
N2  - Alkilaminofenoller antikanser aktivitelerinesahip iyi bilinen organik yapılardır. Bu çalışmada, yüksek verimlerle petasisreaksiyonuyla bir seri (4,5,6) alkilaminofenol bileşiği sentezlendi.Sentezlenen bileşikler 'H-NMR ve 13C-NMR ile karakterize edildi.Ardından,bu bileşiklerin antimikrobiyal ve antioksidan aktivitelerini incelendi.Elde edilen bileşikler, Gram pozitif ve Gram negatif bakterilere karşı testedildi. 4 nolu bileşiğin , 10 mg / mL konsantrasyonda antimikrobiyal aktivitegösterirken, 6 nolu bileşiğin, S. aureus'ta aktivite gösterdiği görüldü.Fenolik bileşikler proksimal ve antioksidan aktivitelerinden dolayı dikkatçekici yapılardır. Alkilaminofenoller fenolik yapıya sahip olduklarındanantioksidan aktiviteleri de araştırılmıştır. Diyabete, kalp hastalığına vekansere karşı yüksek antioksidan kapasiteye sahip ilaç aktif maddeleri; ilk kez sentezlenmiştir.
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UR  - https://doi.org/10.31590/ejosat.582483
L1  - https://dergipark.org.tr/en/download/article-file/769294
ER  -