TY  - JOUR
T1  - GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME
TT  - ŞİZOFRENİDE TEDAVİYE DİRENÇ NEDENİ OLARAK GENETİK SENDROMLAR: TRİPLE X SENDROMLU BİR OLGU
AU  - Esin, İbrahim Selçuk
AU  - Turan, Bahadır
AU  - Akıncı, Mehmet Akif
AU  - Dursun, Onur Burak
PY  - 2019
DA  - July
DO  - 10.26650/IUITFD.2019.0011
JF  - Journal of Istanbul Faculty of Medicine
JO  - İst Tıp Fak Derg
PB  - Istanbul University
WT  - DergiPark
SN  - 1305-6441
SP  - 162
EP  - 163
VL  - 82
IS  - 3
LA  - en
AB  - Triple X syndrome (47, XXX) is a numerical chromosomal alteration that affects 1/1.000 females, in which the individual is born with an extra X chromosome. Trisomy X is a relatively common but under- recognized chromosomal disorder associated with characteristic cognitive and behavioural features of varying severity. We report a 16-year old patient with Triple X syndrome and resistant schizophrenia. It is remarkable that genetic syndromes may be associated with resistance to treatment of psychiatric problems. Therefore in cases with treatment resistance, the genetic analysis should absolutely be examined.
KW  - Schizophrenia
KW  - treatment resistance
KW  - Triple X syndrome
N2  - Amaç: Triple X sendromu (47, XXX), kadınlarda ekstra bir X kromozomunun varlığı ile karakterize, 1/1.000 kişide bir görülen bir sendromdur. Trizomi X, değişken şiddette bilişsel ve davranışsal özelliklerle karakterize bir kromozomal hastalıktır. Bu olgu sunumunda; Triple X sendromlu ve dirençli şizofreni tanısı alan 16 yaşında bir vaka sunuyoruz. Genetik sendromların psikiyatrik problemlerin tedavisinde tedaviye dirençle ilişkili olabileceği ve bu nedenle tedaviye dirençli olgularda genetik analizlerin mutlaka yapılması gerektiği göz önünde bulundurulmalıdır.
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CR  - 3. Otter M, Schrander-Stumpel CT, Curfs LM. Triple X syndrome: a review of the literature. Eur J Hum Genet. 2010;18(3):265.
CR  - 4. Lenroot RK, Blumenthal JD, Wallace GL, Clasen LS, Lee NR, Giedd JN. A case-control study of brain structure and behavioral characteristics in 47, XXX syndrome. Genes Brain Behav. 2014;13(8):841-9.
UR  - https://doi.org/10.26650/IUITFD.2019.0011
L1  - https://dergipark.org.tr/en/download/article-file/749594
ER  -