@article{article_588260, title={Are Hematological Parameters Useful In The Evaluation Of Behçet’s Disease?}, journal={Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi}, volume={52}, pages={245–250}, year={2019}, author={Can Sandıkçı, Sevinç and Omma, Ahmet}, keywords={Behçet’s disease (BD),Hematological parameters,Disease activity}, abstract={<p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span style="font-size:11pt;line-height:150%;font-family:’Times New Roman’;">Objective: </span> </b> <span style="font-size:11pt;line-height:150%;font-family:’Times New Roman’;color:#000000;background:#FFFFFF;">Behçet’s disease (BD)
is an autoinflammatory disease. Hematological indices have been
investigated in many diseases as a marker of inflammation. </span> <span style="font-size:11pt;line-height:150%;font-family:’Times New Roman’;"> </span> <span style="font-size:11pt;line-height:150%;font-family:’Times New Roman’;">The aim of this study was to
evaluate hemogram parameters <span style="color:#131413;">[ </span> </span> <span style="font-size:11pt;line-height:150%;font-family:’Times New Roman’;color:#000000;background:#FFFFFF;">neutrophil–lymphocyte
ratio (NLR), platelet–lymphocyte ratio (PLR), mean platelet volume (MPV), red
blood cell distribution width (RDW), and platelet distribution width (PDW)] </span> <span style="font-size:11pt;line-height:150%;font-family:’Times New Roman’;color:#131413;"> in patients with BD as a marker of disease activity and to
determine associations with different clinical manifestations. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span style="font-size:11pt;line-height:150%;font-family:’Times New Roman’;">Material
and Methods: </span> </b> <span style="font-size:11pt;line-height:150%;font-family:’Times New Roman’;">This single-centre, cross-sectional study
included 141 ( <span class="A16">80 male, 61 female) </span> Behcet’s disease (BD)
patients and 96 ( <span class="A16">51 male, 45 female </span>) healthy subjects.
Hematological and inflammatory parameters including C-reactive protein (CRP),
and erythrocyte sedimentation rate (ESR) were examined in the BD and healthy
control groups. Disease activity in the BD patients was assessed using the
Behçet’s Disease Current Activity Form (BDCAF). <span>  </span> </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span style="font-size:11pt;line-height:150%;font-family:’Times New Roman’;">Results: </span> </b> <span style="font-size:11pt;line-height:150%;font-family:’Times New Roman’;">The </span> <span style="font-size:11pt;line-height:150%;font-family:’Times New Roman’;">N </span> <span style="font-size:11pt;line-height:150%;font-family:’Times New Roman’;">LR
and RDW levels were found to be statistically significantly higher in the BD
group compared to the healthy control group. MPV levels were lower in the BD
group than in the control group. The level of hemogram parameters were similar
in active and inactive disease. NLR and PDW values were found to be
statistically higher in the BD group with major organ involvement group
compared to the mucocutaneous BD group. </span> </p> <p> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span style="font-size:11pt;line-height:150%;font-family:’Times New Roman’;">Conclusions: </span> </b> <span style="font-size:11pt;line-height:150%;font-family:’Times New Roman’;"> The
present study results demonstrated that <span style="color:#131413;">inflammatory
indicators may not provide enough information about disease activity in
patients with BD </span>. NLR and PDW <span style="color:#131413;">both showed
good association with major organ involvement in BD. NLR was found to be much
more suitable to follow up patients with uveitis, MPV for those with erythema
nodosum and PDW for neuro-Behcet and oral ulcers. </span> <b> </b> </span> </p> <p> <b> </b> </p> <b> </b>}, number={3}, publisher={Sağlık Bakanlığı Ankara Eğitim ve Araştırma Hastanesi}